Detailed information of TA system TA202588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 14063..14688
• Replicon: plasmid pCFSAN008081
• Accession: NZ_CP074664
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BG493_RS23630
• Protein ID: WP_000911322.1
• Coordinates: 14290..14688 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BG493_RS23625
• Protein ID: WP_000450265.1
• Coordinates: 14063..14290 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG493_RS23625 (BG493_23610)	14063..14290	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
BG493_RS23630 (BG493_23615)	14290..14688	+	399	WP_000911322.1	type II toxin-antitoxin system VapC family toxin	Toxin
BG493_RS23635 (BG493_23620)	14697..16859	-	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
BG493_RS23640 (BG493_23625)	17236..17967	-	732	WP_000782438.1	conjugal transfer complement resistance protein TraT	-
BG493_RS23645 (BG493_23630)	18003..18497	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	rck / spvB / spvC / fdeC / pefB / pefA / pefC / pefD	1..93960	93960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14887.13 Da
• Isoelectric Point: 8.5264

>T202588 WP_000911322.1 NZ_CP074664:14290-14688 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T202588 NZ_CP099512:30017-30433 [Lelliottia amnigena]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8509.49 Da
• Isoelectric Point: 4.5358

>AT202588 WP_000450265.1 NZ_CP074664:14063-14290 [Salmonella enterica subsp. enterica serovar Typhimurium]
METSVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT202588 NZ_CP099512:29790-30020 [Lelliottia amnigena]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA