Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4350856..4351637 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag BG493_RS21160 Protein ID WP_000626099.1
Coordinates 4350856..4351347 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag BG493_RS21165 Protein ID WP_001110452.1
Coordinates 4351344..4351637 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS21125 (4346851) 4346851..4347426 + 576 WP_001188509.1 transcriptional regulator -
BG493_RS21135 (4347697) 4347697..4347774 - 78 Protein_4147 helix-turn-helix domain-containing protein -
BG493_RS21140 (4347865) 4347865..4348197 - 333 WP_001165471.1 MerR family transcriptional regulator -
BG493_RS21145 (4348269) 4348269..4348646 + 378 WP_000916345.1 EthD family reductase -
BG493_RS21150 (4349679) 4349679..4349753 + 75 Protein_4150 porin family protein -
BG493_RS21155 (4349856) 4349856..4350608 + 753 WP_000842434.1 non-specific acid phosphatase -
BG493_RS21160 (4350856) 4350856..4351347 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
BG493_RS21165 (4351344) 4351344..4351637 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
BG493_RS21170 (4351954) 4351954..4352175 + 222 WP_001576552.1 hypothetical protein -
BG493_RS21175 (4352440) 4352440..4353315 + 876 WP_000921674.1 AraC family transcriptional regulator -
BG493_RS21180 (4353312) 4353312..4353599 + 288 WP_001269916.1 transcriptional regulator RtsB -
BG493_RS21185 (4353622) 4353622..4353837 + 216 WP_001595136.1 hypothetical protein -
BG493_RS21190 (4353845) 4353845..4354114 + 270 WP_010989096.1 hypothetical protein -
BG493_RS21195 (4354408) 4354408..4355313 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T202585 WP_000626099.1 NZ_CP074663:c4351347-4350856 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202585 NZ_CP099511:3357083-3357400 [Lelliottia amnigena]
ATGAAGGAGATTGTTCAAACAGAATCCTTCCGTTGCTGGGAGCAAAACGTAAACGATCCACGTGCAAAAACGCTTATTGC
AGCGCGTTTATTCCGCCTGGCTAATGGTCTGCCGGGGGATGTAAAACCTGTTGGAGAAGGTATCAGCGAGCTACGCATTC
ATTACGGCCCGGGTTACAGGATCTATTTTAAATCGCAGGGAAACGTACTGATCATTTTGCTCAGTGGCGGCAATAAAAAC
AGTCAGGATAAAGACATCATTCTGGCAAAGACACTCGCAAGGTCACTCGAAAATCGGGAGTTTATACACCATGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT202585 WP_001110452.1 NZ_CP074663:c4351637-4351344 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202585 NZ_CP099511:3357393-3357680 [Lelliottia amnigena]
ATGACTGAACTCACTCATTACGATCCTGCCAGGGCGCTTATCAATGATGATGAAATTAGCGTATTCATGGCTGATGCGCT
AGAAACTGGCGATTCTGCCTACATTGCTAAAGCATTAGGGATCGTTGCCCGCACAAAAGGAATGTCTACCATTGCGACAC
AAACGGGTTTGTCTCGCGAACAGCTGTATCGCTCTTTTAGTGAAAAAGGTAACCCAACGCTTAAAACCACGCTTGCCGTT
ATGAAAGCGCTGGGTCTTGGATTGACGATTAAAAGTGCTGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References