Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4127968..4128544 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag BG493_RS20095 Protein ID WP_001131963.1
Coordinates 4128257..4128544 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag BG493_RS20090 Protein ID WP_000063142.1
Coordinates 4127968..4128270 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS20075 (4124478) 4124478..4126628 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
BG493_RS20080 (4126723) 4126723..4126926 + 204 WP_000460616.1 YbdD/YjiX family protein -
BG493_RS20085 (4126937) 4126937..4127893 + 957 WP_000187839.1 GTPase -
BG493_RS20090 (4127968) 4127968..4128270 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
BG493_RS20095 (4128257) 4128257..4128544 - 288 WP_001131963.1 BrnT family toxin Toxin
BG493_RS20100 (4128813) 4128813..4129727 - 915 WP_000290512.1 restriction endonuclease -
BG493_RS20105 (4129925) 4129925..4133434 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T202583 WP_001131963.1 NZ_CP074663:c4128544-4128257 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T202583 NZ_CP099511:c3087003-3086683 [Lelliottia amnigena]
ATGCAAATTTCAACTGTACCGGCTACGGTGCCGGTTTCGCCACGCCTGTCGCCCGTTCAGGTATGGCAGCAATTGCTATC
GTATCTGTTGGAACACCATTACGGTCTCATGCTTAACGACACCCCCTTTCATTACGATGCAGCAATCCTGGAGCATATCG
AAGCGAGAATAACGCTGGCTGATGCGGTAAATTTCCTGGTGGATCGCTATGAACTGGTACGCATCGACCGCAAAGGATTT
AGCTGGCAGGAACAGGAACCGTTTCTTACCGCTGCTGATATTCTCAGGGCAAAACGTGCTACCGGATTAATGAATACTTA
A

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT202583 WP_000063142.1 NZ_CP074663:c4128270-4127968 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT202583 NZ_CP099511:c3087356-3087036 [Lelliottia amnigena]
ATGAAATCAACACTCCATGAATGGGGGCTCCAACCCGATATTTCACCACGATTTGGCGCCAGGCTGGTTCAGGAAGGCAA
CAGGTTGCATTATCTGGCCGACAGAGCTGCTTTTGCCGGAAGTTTCACCCCCGAGCAGTTACAAAAACTCGAACAGGTTT
TCCCTCTACTACTAGAACACCTGGAAAATATGCTGTGTTCCGGCGAGCTCAATCCTCGTTGGCAACATCAGGTGAAGATT
CACCTTGCCGGATTAACATGTGTCGCTGATACCGGTGCCAGTTGCGGCTACGTTTACATTTCAATTTATCCAGCTCAGTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References