Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3514823..3515443 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag BG493_RS17270 Protein ID WP_001280991.1
Coordinates 3515225..3515443 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag BG493_RS17265 Protein ID WP_000344807.1
Coordinates 3514823..3515197 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS17255 (3509978) 3509978..3511171 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BG493_RS17260 (3511194) 3511194..3514327 + 3134 Protein_3389 efflux RND transporter permease AcrB -
BG493_RS17265 (3514823) 3514823..3515197 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
BG493_RS17270 (3515225) 3515225..3515443 + 219 WP_001280991.1 HHA domain-containing protein Toxin
BG493_RS17275 (3515622) 3515622..3516173 + 552 WP_001278792.1 maltose O-acetyltransferase -
BG493_RS17280 (3516290) 3516290..3516760 + 471 WP_000136181.1 YlaC family protein -
BG493_RS17285 (3516816) 3516816..3516956 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
BG493_RS17290 (3516962) 3516962..3517222 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
BG493_RS17295 (3517447) 3517447..3518997 + 1551 WP_000213139.1 EAL domain-containing protein -
BG493_RS17305 (3519228) 3519228..3519617 + 390 WP_000961285.1 MGMT family protein -
BG493_RS17310 (3519650) 3519650..3520219 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202579 WP_001280991.1 NZ_CP074663:3515225-3515443 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202579 NZ_CP099511:42474-42887 [Lelliottia amnigena]
GTGGTCCTGTGGCAATCTGATCTGCGCGTATCCTGGCGCTCACAGTGGATGTCTTTGTTGCTCCACGGAATGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCACTCAGCTACACCCCGTTATGGATGCTGTTACTCTCGCTTGTGGTGTTCGACAGCG
TGCGCAGCCAGCGACGTATCAATTCCTGTCAGGGCGAAATCAAGCTGCTGATGGACTCTCGTCTGCGCTGGCAAGGTAAA
GAGTGGGAAATCGTTGGTACGCCCTGGATGCTGAGTTTTGGCATGATGTTTCGCTTGCGTAACGTGCAAGGCGGACGAAA
CCAGCATTTATGGCTTTCGGCGGACAGTATGGATGCTGACGAATGGCGAGATTTGCGTCGGATGGTTTTGCAGCAACCGA
CGCCCGGTCGATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202579 WP_000344807.1 NZ_CP074663:3514823-3515197 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202579 NZ_CP099511:42227-42493 [Lelliottia amnigena]
ATGGACATTAGCAATAAGGCTCGTATTCACTGGGCGTGCCGCCGCGGCATGCGCGAACTTGATATTTCCGTCATGCCATT
CTTCGAATATGAATACGACAGCTTAAGCGATGACGATAAGCGTCTGTTTATTCGCCTTCTTGAAAGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References