Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839399..840059 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag BG493_RS04045 Protein ID WP_000244756.1
Coordinates 839646..840059 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag BG493_RS04040 Protein ID WP_000351186.1
Coordinates 839399..839665 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS04020 (835327) 835327..836760 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
BG493_RS04025 (836919) 836919..837230 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
BG493_RS04030 (837394) 837394..838053 + 660 WP_000250289.1 hemolysin III family protein -
BG493_RS04035 (838169) 838169..839149 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
BG493_RS04040 (839399) 839399..839665 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
BG493_RS04045 (839646) 839646..840059 + 414 WP_000244756.1 protein YgfX Toxin
BG493_RS04050 (840112) 840112..840633 - 522 WP_001055885.1 flavodoxin FldB -
BG493_RS04055 (840746) 840746..841642 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
BG493_RS04060 (841666) 841666..842379 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BG493_RS04065 (842385) 842385..844118 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202567 WP_000244756.1 NZ_CP074663:839646-840059 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202567 NZ_CP099506:c1734142-1733780 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202567 WP_000351186.1 NZ_CP074663:839399-839665 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202567 NZ_CP099506:c1734309-1734139 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References