Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 317049..317635 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag BG493_RS01455 Protein ID WP_001521773.1
Coordinates 317267..317635 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag BG493_RS01450 Protein ID WP_001520924.1
Coordinates 317049..317270 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS01425 (312069) 312069..313178 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
BG493_RS01430 (313238) 313238..314164 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
BG493_RS01435 (314161) 314161..315438 + 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
BG493_RS01440 (315435) 315435..316202 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
BG493_RS01445 (316204) 316204..316917 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
BG493_RS01450 (317049) 317049..317270 + 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BG493_RS01455 (317267) 317267..317635 + 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BG493_RS01460 (317894) 317894..319210 + 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
BG493_RS01465 (319274) 319274..320161 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
BG493_RS01470 (320158) 320158..321003 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
BG493_RS01475 (321005) 321005..322075 + 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 306828..322812 15984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T202565 WP_001521773.1 NZ_CP074663:317267-317635 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T202565 NZ_CP099506:c1567620-1567513 [Staphylococcus aureus]
GTGGTATCTATTGTTGATGCACTAAATTTGATGTTTAGTTTCGGTATGTTTATCGTTACTTTACTTGGTTTGGTCATCGC
AATCGTTAAATTAAATCACAAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT202565 WP_001520924.1 NZ_CP074663:317049-317270 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT202565 NZ_CP099506:1567395-1567488 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTTTTATATGAT
TAATAAATAACCAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References