Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206515..207275 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag BG493_RS00970 Protein ID WP_000533909.1
Coordinates 206790..207275 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag BG493_RS00965 Protein ID WP_000965886.1
Coordinates 206515..206802 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS00940 (201810) 201810..202112 + 303 WP_000605590.1 YsaB family lipoprotein -
BG493_RS00945 (202251) 202251..203162 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
BG493_RS00950 (203172) 203172..205241 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
BG493_RS00955 (205423) 205423..205698 + 276 Protein_189 IS3 family transposase -
BG493_RS00960 (205870) 205870..206337 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
BG493_RS00965 (206515) 206515..206802 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
BG493_RS00970 (206790) 206790..207275 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
BG493_RS00975 (207647) 207647..208186 - 540 Protein_193 copper-binding periplasmic metallochaperone CueP -
BG493_RS00980 (208360) 208360..208572 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
BG493_RS00985 (208861) 208861..209151 - 291 WP_000455790.1 HTH-type transcriptional regulator -
BG493_RS00990 (209590) 209590..210300 + 711 WP_000190524.1 DUF3053 domain-containing protein -
BG493_RS00995 (210350) 210350..211324 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
BG493_RS01000 (211543) 211543..212205 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T202564 WP_000533909.1 NZ_CP074663:206790-207275 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202564 NZ_CP099506:c1532916-1532764 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202564 WP_000965886.1 NZ_CP074663:206515-206802 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202564 NZ_CP099506:c1533540-1532941 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References