Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4061377..4061893 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag A9D71_RS19690 Protein ID WP_000220582.1
Coordinates 4061377..4061661 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A9D71_RS19695 Protein ID WP_000212724.1
Coordinates 4061651..4061893 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS19675 (4056588) 4056588..4058240 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
A9D71_RS19680 (4058649) 4058649..4060787 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
A9D71_RS19685 (4060909) 4060909..4061373 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A9D71_RS19690 (4061377) 4061377..4061661 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9D71_RS19695 (4061651) 4061651..4061893 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A9D71_RS19700 (4061971) 4061971..4063884 - 1914 WP_001212142.1 BglG family transcription antiterminator -
A9D71_RS19705 (4063901) 4063901..4064641 - 741 WP_000779259.1 KDGP aldolase family protein -
A9D71_RS19710 (4064638) 4064638..4065756 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A9D71_RS19715 (4065740) 4065740..4066873 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T202559 WP_000220582.1 NZ_CP074661:c4061661-4061377 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202559 NZ_CP099504:2288863-2289225 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202559 WP_000212724.1 NZ_CP074661:c4061893-4061651 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202559 NZ_CP099504:2288696-2288866 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References