Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4020252..4020802 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag A9D71_RS19480 Protein ID WP_001199743.1
Coordinates 4020252..4020560 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag A9D71_RS19485 Protein ID WP_001118105.1
Coordinates 4020563..4020802 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS19460 (4016826) 4016826..4017566 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
A9D71_RS19465 (4017688) 4017688..4018218 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
A9D71_RS19470 (4018541) 4018541..4019674 + 1134 Protein_3820 IS3 family transposase -
A9D71_RS19475 (4019706) 4019706..4019846 - 141 Protein_3821 Arm DNA-binding domain-containing protein -
A9D71_RS19480 (4020252) 4020252..4020560 - 309 WP_001199743.1 CcdB family protein Toxin
A9D71_RS19485 (4020563) 4020563..4020802 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
A9D71_RS19490 (4020911) 4020911..4021159 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
A9D71_RS19495 (4021350) 4021350..4021781 - 432 Protein_3825 helix-turn-helix domain-containing protein -
A9D71_RS19505 (4022538) 4022538..4023557 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
A9D71_RS19510 (4023585) 4023585..4024115 - 531 WP_000896758.1 gluconokinase -
A9D71_RS19515 (4024332) 4024332..4025363 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4000843..4021159 20316
- inside IScluster/Tn - - 4018633..4021736 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T202558 WP_001199743.1 NZ_CP074661:c4020560-4020252 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T202558 NZ_CP099504:2269276-2269485 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT202558 WP_001118105.1 NZ_CP074661:c4020802-4020563 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT202558 NZ_CP099504:2268971-2269264 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References