Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3969985..3970561 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag A9D71_RS19255 Protein ID WP_001131963.1
Coordinates 3970274..3970561 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag A9D71_RS19250 Protein ID WP_000063142.1
Coordinates 3969985..3970287 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS19235 (3966495) 3966495..3968645 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
A9D71_RS19240 (3968740) 3968740..3968943 + 204 WP_000460616.1 YbdD/YjiX family protein -
A9D71_RS19245 (3968954) 3968954..3969910 + 957 WP_000187843.1 GTPase -
A9D71_RS19250 (3969985) 3969985..3970287 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
A9D71_RS19255 (3970274) 3970274..3970561 - 288 WP_001131963.1 BrnT family toxin Toxin
A9D71_RS19260 (3970985) 3970985..3972826 + 1842 WP_000974636.1 nuclease-related domain-containing DEAD/DEAH box helicase -
A9D71_RS19265 (3973439) 3973439..3974014 + 576 WP_000593784.1 restriction endonuclease subunit S -
A9D71_RS19270 (3974019) 3974019..3975272 + 1254 WP_001206755.1 N-6 DNA methylase -
A9D71_RS23155 (3975304) 3975304..3975438 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T202557 WP_001131963.1 NZ_CP074661:c3970561-3970274 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T202557 NZ_CP099504:1947879-1948145 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT202557 WP_000063142.1 NZ_CP074661:c3970287-3969985 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT202557 NZ_CP099504:1947628-1947879 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References