Detailed information of TA system TA202538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 310292..310878
• Replicon: chromosome
• Accession: NZ_CP074661
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: A9D71_RS01415
• Protein ID: WP_000174964.1
• Coordinates: 310510..310878 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: A9D71_RS01410
• Protein ID: WP_001522145.1
• Coordinates: 310292..310513 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9D71_RS01385 (305313)	305313..306422	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
A9D71_RS01390 (306482)	306482..307408	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
A9D71_RS01395 (307405)	307405..308682	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
A9D71_RS01400 (308679)	308679..309446	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
A9D71_RS01405 (309448)	309448..310161	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
A9D71_RS01410 (310292)	310292..310513	+	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A9D71_RS01415 (310510)	310510..310878	+	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
A9D71_RS01420 (311137)	311137..312453	+	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
A9D71_RS01425 (312558)	312558..313445	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
A9D71_RS01430 (313442)	313442..314287	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
A9D71_RS01435 (314289)	314289..315359	+	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	283128..316096	32968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T202538 WP_000174964.1 NZ_CP074661:310510-310878 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T202538 NZ_CP099497:c522309-522121 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT202538 WP_001522145.1 NZ_CP074661:310292-310513 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT202538 NZ_CP099497:c522597-522337 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4