Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200176..200936 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag A9D71_RS00930 Protein ID WP_000533912.1
Coordinates 200451..200936 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag A9D71_RS00925 Protein ID WP_000965886.1
Coordinates 200176..200463 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS00905 (195581) 195581..196492 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
A9D71_RS00910 (196502) 196502..198571 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
A9D71_RS22960 (198961) 198961..199359 + 399 Protein_181 IS3 family transposase -
A9D71_RS00920 (199531) 199531..199998 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
A9D71_RS00925 (200176) 200176..200463 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
A9D71_RS00930 (200451) 200451..200936 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
A9D71_RS00935 (201307) 201307..201846 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
A9D71_RS00940 (202020) 202020..202232 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
A9D71_RS00945 (202520) 202520..202810 - 291 WP_000455790.1 HTH-type transcriptional regulator -
A9D71_RS00950 (203249) 203249..203959 + 711 WP_000190524.1 DUF3053 domain-containing protein -
A9D71_RS00955 (204009) 204009..204983 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
A9D71_RS00960 (205202) 205202..205864 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T202537 WP_000533912.1 NZ_CP074661:200451-200936 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T202537 NZ_CP099495:2638364-2638726 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT202537 WP_000965886.1 NZ_CP074661:200176-200463 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT202537 NZ_CP099495:2638197-2638367 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References