Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4236026..4236542 Replicon chromosome
Accession NZ_CP074606
Organism Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DLM99_RS20695 Protein ID WP_000220578.1
Coordinates 4236026..4236310 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DLM99_RS20700 Protein ID WP_000212724.1
Coordinates 4236300..4236542 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLM99_RS20680 (4231141) 4231141..4232793 + 1653 WP_000155041.1 alpha,alpha-phosphotrehalase -
DLM99_RS20685 (4233203) 4233203..4235341 + 2139 WP_000187822.1 anaerobic ribonucleoside-triphosphate reductase -
DLM99_RS20690 (4235558) 4235558..4236022 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DLM99_RS20695 (4236026) 4236026..4236310 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLM99_RS20700 (4236300) 4236300..4236542 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DLM99_RS20705 (4236620) 4236620..4238533 - 1914 WP_001212148.1 BglG family transcription antiterminator -
DLM99_RS20710 (4238550) 4238550..4239290 - 741 WP_000779264.1 KDGP aldolase family protein -
DLM99_RS20715 (4239287) 4239287..4240405 - 1119 WP_001139176.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DLM99_RS20720 (4240389) 4240389..4241522 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T202534 WP_000220578.1 NZ_CP074606:c4236310-4236026 [Salmonella enterica subsp. enterica serovar Newport str.]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202534 NZ_CP099495:2263988-2264095 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202534 WP_000212724.1 NZ_CP074606:c4236542-4236300 [Salmonella enterica subsp. enterica serovar Newport str.]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202534 NZ_CP099495:c2264172-2264112 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References