Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4134661..4135237 Replicon chromosome
Accession NZ_CP074606
Organism Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)


Gene name shpA Uniprot ID A0A3V9WZB2
Locus tag DLM99_RS20225 Protein ID WP_001131962.1
Coordinates 4134950..4135237 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag DLM99_RS20220 Protein ID WP_000063143.1
Coordinates 4134661..4134963 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLM99_RS20205 (4131171) 4131171..4133321 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
DLM99_RS20210 (4133416) 4133416..4133619 + 204 WP_000460616.1 YbdD/YjiX family protein -
DLM99_RS20215 (4133630) 4133630..4134586 + 957 WP_000187835.1 GTPase -
DLM99_RS20220 (4134661) 4134661..4134963 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
DLM99_RS20225 (4134950) 4134950..4135237 - 288 WP_001131962.1 BrnT family toxin Toxin
DLM99_RS20230 (4135647) 4135647..4137488 + 1842 WP_000974634.1 nuclease-related domain-containing DEAD/DEAH box helicase -
DLM99_RS20235 (4138101) 4138101..4138676 + 576 WP_000593785.1 restriction endonuclease subunit S -
DLM99_RS20240 (4138681) 4138681..4139934 + 1254 WP_001206757.1 N-6 DNA methylase -
DLM99_RS24070 (4139966) 4139966..4140100 - 135 WP_001055726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11326.86 Da        Isoelectric Point: 9.5894

>T202532 WP_001131962.1 NZ_CP074606:c4135237-4134950 [Salmonella enterica subsp. enterica serovar Newport str.]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIMVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T202532 NZ_CP099495:119896-120048 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT202532 WP_000063143.1 NZ_CP074606:c4134963-4134661 [Salmonella enterica subsp. enterica serovar Newport str.]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT202532 NZ_CP099495:119272-119871 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9WZB2

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References