Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521775..3522395 Replicon chromosome
Accession NZ_CP074606
Organism Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DLM99_RS17390 Protein ID WP_001280991.1
Coordinates 3522177..3522395 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DLM99_RS17385 Protein ID WP_000344807.1
Coordinates 3521775..3522149 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLM99_RS17375 (3516914) 3516914..3518107 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DLM99_RS17380 (3518130) 3518130..3521279 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DLM99_RS17385 (3521775) 3521775..3522149 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DLM99_RS17390 (3522177) 3522177..3522395 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DLM99_RS17395 (3522574) 3522574..3523125 + 552 WP_001278792.1 maltose O-acetyltransferase -
DLM99_RS17400 (3523242) 3523242..3523712 + 471 WP_000136181.1 YlaC family protein -
DLM99_RS17405 (3523768) 3523768..3523908 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DLM99_RS17410 (3523914) 3523914..3524174 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DLM99_RS17415 (3524399) 3524399..3525949 + 1551 WP_000213128.1 EAL domain-containing protein -
DLM99_RS17425 (3526180) 3526180..3526569 + 390 WP_000961285.1 MGMT family protein -
DLM99_RS17430 (3526602) 3526602..3527171 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202528 WP_001280991.1 NZ_CP074606:3522177-3522395 [Salmonella enterica subsp. enterica serovar Newport str.]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202528 NZ_CP099490:c3547666-3547418 [Ornithinimicrobium cryptoxanthini]
ATGTCCATCACCGCAAGCGAGGCCCGCAAGCGCCTCTTCCCCCTGATCGAGCAGGTCAACGATGACCGAGCTCCAGTGGA
GATCACCTCGAAGCGAGGCAACGCGGTACTCATGTCAGCCGAGGACTACTCGGCTTGGCAGGAGACGGCCTATCTGTTTC
GCTCTCCCGCCAACGCACGGAGACTGCTTGATGCCATGGAGGCGGTGGACCGCGGCGAAGGGGCTGAACGCGAACTTGAT
CGCACATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202528 WP_000344807.1 NZ_CP074606:3521775-3522149 [Salmonella enterica subsp. enterica serovar Newport str.]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202528 NZ_CP099490:c3547421-3547161 [Ornithinimicrobium cryptoxanthini]
ATGAGGCCCGTCTTCGCGCCTCAGGCGTGGGAGGACTACCTCCACTGGCAACGCATCGATCGGACCGTGGTGAAGCGGAT
CAACCGGCTGATCGATGACGCGACTCGGGACCCTTTCGCCGGAGTCGGCAAACCCGAGCCACTGAAGTACGGGCTGGCTC
ATGCCTGGTCGCGGCGCATCAACGAGGAGCACCGGTTGGTCTACGTGGTCCGAGACGATGACCTCGTCCTCCTACAAGCC
CGCTACCACTACACGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References