Detailed information of TA system TA202527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2419890..2420412
• Replicon: chromosome
• Accession: NZ_CP074606
• Organism: Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: DLM99_RS11780
• Protein ID: WP_000221343.1
• Coordinates: 2420128..2420412 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: DLM99_RS11775
• Protein ID: WP_000885424.1
• Coordinates: 2419890..2420138 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLM99_RS11745 (2415284)	2415284..2416498	-	1215	WP_119471953.1	MalY/PatB family protein	-
DLM99_RS11750 (2416642)	2416642..2417649	-	1008	WP_000201071.1	LacI family DNA-binding transcriptional regulator	-
DLM99_RS11755 (2417979)	2417979..2418167	+	189	WP_001276020.1	DUF29 family protein	-
DLM99_RS11760 (2418546)	2418546..2418791	+	246	WP_223169108.1	helix-turn-helix domain-containing protein	-
DLM99_RS23965 (2418781)	2418781..2418921	-	141	Protein_2316	hypothetical protein	-
DLM99_RS11765 (2419201)	2419201..2419533	-	333	WP_000253158.1	DUF1493 family protein	-
DLM99_RS11770 (2419523)	2419523..2419738	-	216	WP_000206204.1	hypothetical protein	-
DLM99_RS11775 (2419890)	2419890..2420138	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DLM99_RS11780 (2420128)	2420128..2420412	+	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DLM99_RS11785 (2420583)	2420583..2420972	+	390	WP_000194089.1	RidA family protein	-
DLM99_RS11790 (2421024)	2421024..2422103	-	1080	WP_000954698.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
DLM99_RS11795 (2422296)	2422296..2422784	-	489	WP_001293638.1	MarR family winged helix-turn-helix transcriptional regulator	-
DLM99_RS11800 (2422829)	2422829..2424337	+	1509	WP_000199416.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T202527 WP_000221343.1 NZ_CP074606:2420128-2420412 [Salmonella enterica subsp. enterica serovar Newport str.]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T202527 NZ_CP099490:c3547421-3547161 [Ornithinimicrobium cryptoxanthini]
ATGAGGCCCGTCTTCGCGCCTCAGGCGTGGGAGGACTACCTCCACTGGCAACGCATCGATCGGACCGTGGTGAAGCGGAT
CAACCGGCTGATCGATGACGCGACTCGGGACCCTTTCGCCGGAGTCGGCAAACCCGAGCCACTGAAGTACGGGCTGGCTC
ATGCCTGGTCGCGGCGCATCAACGAGGAGCACCGGTTGGTCTACGTGGTCCGAGACGATGACCTCGTCCTCCTACAAGCC
CGCTACCACTACACGAAGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT202527 WP_000885424.1 NZ_CP074606:2419890-2420138 [Salmonella enterica subsp. enterica serovar Newport str.]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT202527 NZ_CP099490:c3547666-3547418 [Ornithinimicrobium cryptoxanthini]
ATGTCCATCACCGCAAGCGAGGCCCGCAAGCGCCTCTTCCCCCTGATCGAGCAGGTCAACGATGACCGAGCTCCAGTGGA
GATCACCTCGAAGCGAGGCAACGCGGTACTCATGTCAGCCGAGGACTACTCGGCTTGGCAGGAGACGGCCTATCTGTTTC
GCTCTCCCGCCAACGCACGGAGACTGCTTGATGCCATGGAGGCGGTGGACCGCGGCGAAGGGGCTGAACGCGAACTTGAT
CGCACATGA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5