Detailed information of TA system TA202518

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 837459..838084
• Replicon: chromosome
• Accession: NZ_CP074606
• Organism: Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DLM99_RS04030
• Protein ID: WP_000911337.1
• Coordinates: 837686..838084 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: DLM99_RS04025
• Protein ID: WP_000557545.1
• Coordinates: 837459..837686 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLM99_RS03995 (832504)	832504..834021	+	1518	WP_000003339.1	lysine--tRNA ligase	-
DLM99_RS04000 (834097)	834097..834642	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
DLM99_RS04005 (834907)	834907..835665	+	759	WP_000244318.1	amidase activator ActS	-
DLM99_RS04015 (835950)	835950..836756	-	807	WP_079901689.1	DUF1460 domain-containing protein	-
DLM99_RS04020 (837031)	837031..837282	-	252	WP_001668347.1	hypothetical protein	-
DLM99_RS04025 (837459)	837459..837686	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
DLM99_RS04030 (837686)	837686..838084	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
DLM99_RS04035 (838891)	838891..839427	+	537	WP_001038505.1	STM3031 family outer membrane protein	-
DLM99_RS04040 (839474)	839474..840106	+	633	WP_000835265.1	YfdX family protein	-
DLM99_RS04045 (840825)	840825..841409	+	585	WP_001244638.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	835950..845881	9931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T202518 WP_000911337.1 NZ_CP074606:837686-838084 [Salmonella enterica subsp. enterica serovar Newport str.]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T202518 NZ_CP099490:258846-259286 [Ornithinimicrobium cryptoxanthini]
ATGACTGAGCCTCCGGTCACCCTGTTCGACGTCAACGCTCTCGTCGCCGTCGCGCTCACGACGCACCAGCACCACCACGC
CGCGCACCGACACCTGCGCGCCCTTGACGGCACGTGGGCGACTGCCTCCCTCACCGAGGCCGGCCTATTCCGGTTGCTGC
TCAACCCTCTCGTCACTGGTTCACAGCGGCTGGCCGCTGACGTGGGCGCGGTCCTCCAGGGCATGCGGGGTGATCCGCGG
TGGACCTTCCTGGAGGACGCGACCTCGCTGGCCGATCCCATCGTTGACACCACGGTCTTGATGGGTCACCGACAGGTCAC
CGACGTGCATCTGGTCAACCTGGCGGCGCGGCACGGGGGCGTGCTCGCAACCTTCGACGCGGGCATCAGGTCATGGCTCG
CCCCGGAGGATCGTCACCACATCGTCGTGATCCCCGCGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT202518 WP_000557545.1 NZ_CP074606:837459-837686 [Salmonella enterica subsp. enterica serovar Newport str.]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT202518 NZ_CP099490:258626-258853 [Ornithinimicrobium cryptoxanthini]
ATGCGGACCACGCTCGAGATCGACGACCAGGTCATGGCCGCAGCACGCTCACTGGCCCGCAGTCGGGGGACGTCTGTCGG
CGCTGCGGTCTCCGAACTCGCGCGTCGGGGGCTCATGCAGTCGGCAGGTGCGCGAGTCGATGCTCACTACAGTCCGTTCC
CCGTCATGGTCGGCGATGAGGGGGTCCTCGTGACGGATGAGCTCATCGCCGAACTGCGCGATGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6