Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 826572..827232 Replicon chromosome
Accession NZ_CP074606
Organism Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DLM99_RS03965 Protein ID WP_000244756.1
Coordinates 826819..827232 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DLM99_RS03960 Protein ID WP_000351186.1
Coordinates 826572..826838 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLM99_RS03940 (822499) 822499..823932 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
DLM99_RS03945 (824091) 824091..824405 + 315 WP_072600465.1 N(4)-acetylcytidine aminohydrolase -
DLM99_RS03950 (824567) 824567..825226 + 660 WP_000250289.1 hemolysin III family protein -
DLM99_RS03955 (825342) 825342..826322 - 981 WP_000874175.1 tRNA-modifying protein YgfZ -
DLM99_RS03960 (826572) 826572..826838 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DLM99_RS03965 (826819) 826819..827232 + 414 WP_000244756.1 protein YgfX Toxin
DLM99_RS03970 (827285) 827285..827806 - 522 WP_001055885.1 flavodoxin FldB -
DLM99_RS03975 (827919) 827919..828815 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DLM99_RS03980 (828839) 828839..829552 + 714 WP_000745622.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DLM99_RS03985 (829558) 829558..831291 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T202517 WP_000244756.1 NZ_CP074606:826819-827232 [Salmonella enterica subsp. enterica serovar Newport str.]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T202517 NZ_CP099490:c138320-137898 [Ornithinimicrobium cryptoxanthini]
GTGATCATCCTCGACACCAACGTCCTCATCTATTCAGTGCACAAGGGGGCGTCGCAGCACGAGCGCACGGCTCGATGGCT
CGACCGGATGCTGGCGGAGCCACAGGTGCTCGGGCTGCCGTGGGTCGCGGCGCTCGGCTTCATCCGGATCACCACCAACG
CGCGCATCTTCCCTGAGCCGCTCACCGTCGATGAGGCGATGACCGTGCTGGACGCCTGGCACGCCCACCCAGCCGTGACT
CTGCCGCAGCCCACGACCCGCCACCTGTCGGTGCTCTCCGGGTTGTTGCGCGAGGCCGGCACGGCGGGCAATCTGACGAC
CGACGCGCATATCGCCGCCCTAGCCATCGAGCACGGCGCGTCGGTGGCCACCTTTGACCGGGACCTCGCACGCTTTGGTG
TCACGGTCGTCGTGCCGGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202517 WP_000351186.1 NZ_CP074606:826572-826838 [Salmonella enterica subsp. enterica serovar Newport str.]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202517 NZ_CP099490:c138580-138323 [Ornithinimicrobium cryptoxanthini]
ATGCGCACGACCATCACGCTGGACCCCGACGTCACGCTTTTGATCGAGCGTGAGATGGCTGCCCGCAACCTCCGGTTCAA
GCAGGTCGTCAACGAGGCCCTGCGTCGACAGCTCGGCGGAAGCCAAGGTGCACCGCCCAGCCTGACCGACTTCGGACGCG
ACCTCGGCGTGGCAGCCGTGGACCTGACCAAAGCCAACCAGCTCGCCGCAGCCCTGGAGGACGGAGAGCTTCTCCGCAAG
ATGGCGCAGGGCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References