Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 307197..307783 | Replicon | chromosome |
| Accession | NZ_CP074606 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A3V9X0E4 |
| Locus tag | DLM99_RS01400 | Protein ID | WP_000174964.1 |
| Coordinates | 307415..307783 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | V7IU48 |
| Locus tag | DLM99_RS01395 | Protein ID | WP_001522145.1 |
| Coordinates | 307197..307418 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DLM99_RS01370 (302218) | 302218..303327 | + | 1110 | WP_000822976.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
| DLM99_RS01375 (303387) | 303387..304313 | + | 927 | WP_000003007.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| DLM99_RS01380 (304310) | 304310..305587 | + | 1278 | WP_000803764.1 | branched chain amino acid ABC transporter permease LivM | - |
| DLM99_RS01385 (305584) | 305584..306351 | + | 768 | WP_000082081.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| DLM99_RS01390 (306353) | 306353..307066 | + | 714 | WP_000416114.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| DLM99_RS01395 (307197) | 307197..307418 | + | 222 | WP_001522145.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| DLM99_RS01400 (307415) | 307415..307783 | + | 369 | WP_000174964.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| DLM99_RS01405 (308042) | 308042..309358 | + | 1317 | WP_000624747.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| DLM99_RS01410 (309463) | 309463..310350 | + | 888 | WP_000094074.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| DLM99_RS01415 (310347) | 310347..311192 | + | 846 | WP_000572196.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| DLM99_RS01420 (311195) | 311195..312265 | + | 1071 | WP_000907839.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 304310..313002 | 8692 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13601.91 Da Isoelectric Point: 6.7252
>T202516 WP_000174964.1 NZ_CP074606:307415-307783 [Salmonella enterica subsp. enterica serovar Newport str.]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA
Download Length: 369 bp
>T202516 NZ_CP099489:4417668-4418057 [Ornithinimicrobium sp. HY1793]
ATGACCTATCTCCTAGACACCCACGCGGTGCTCTGGGCACTCACCGACCCCGCGCGTCTGGGGCCCGCCGCGCGCCAGAC
CATCACGGCCCGCTCCACCCGACTGGCCGTCTCAGCAGCAACGGCGTGGGAGATCTCCACCAAGCAGCGCATCGGCAAAC
TTCCCCAGGCGGACGCCCTCGTCGGCGGATACTCCCGGCATCTCGATCGGTTGGGTGCCATCAGACTGCCCATCGACGAG
GAACACGCGCTGCTCGCGGGACGGCTGGATTGGTCTCATCGCGATCCGTTTGATCGTGTGTTTGCCGCCCAAGCCATGCT
GGAGTCCCTCACGCTCGTGACGAACGACTCGGCCTTCGCGGAGCTCAACGGGGTCGCCACGCTCTGGTAG
ATGACCTATCTCCTAGACACCCACGCGGTGCTCTGGGCACTCACCGACCCCGCGCGTCTGGGGCCCGCCGCGCGCCAGAC
CATCACGGCCCGCTCCACCCGACTGGCCGTCTCAGCAGCAACGGCGTGGGAGATCTCCACCAAGCAGCGCATCGGCAAAC
TTCCCCAGGCGGACGCCCTCGTCGGCGGATACTCCCGGCATCTCGATCGGTTGGGTGCCATCAGACTGCCCATCGACGAG
GAACACGCGCTGCTCGCGGGACGGCTGGATTGGTCTCATCGCGATCCGTTTGATCGTGTGTTTGCCGCCCAAGCCATGCT
GGAGTCCCTCACGCTCGTGACGAACGACTCGGCCTTCGCGGAGCTCAACGGGGTCGCCACGCTCTGGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8166.17 Da Isoelectric Point: 5.0775
>AT202516 WP_001522145.1 NZ_CP074606:307197-307418 [Salmonella enterica subsp. enterica serovar Newport str.]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK
Download Length: 222 bp
>AT202516 NZ_CP099489:4417441-4417671 [Ornithinimicrobium sp. HY1793]
ATGGAAACGGTCAAGGTGCAATACGCCAAGACGCACTTGTCCGCGCTGCTGGCAGCAGTCGAGCGGGGCGAAGAGATCGT
CATCGCGCGCGGGGACCGCCCCGTCGCCCGGCTGTCCCCGATCGATGGCCAGGACGACCGCGAGCTGGGCTTCGTCGCCT
ACTCAGTGCCTGACGAGTTCTTCGACCCTCTGCCAGAGGAGGAACTCGCTGTGTGGGAGGGCGCGGGATGA
ATGGAAACGGTCAAGGTGCAATACGCCAAGACGCACTTGTCCGCGCTGCTGGCAGCAGTCGAGCGGGGCGAAGAGATCGT
CATCGCGCGCGGGGACCGCCCCGTCGCCCGGCTGTCCCCGATCGATGGCCAGGACGACCGCGAGCTGGGCTTCGTCGCCT
ACTCAGTGCCTGACGAGTTCTTCGACCCTCTGCCAGAGGAGGAACTCGCTGTGTGGGAGGGCGCGGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|