Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 197058..197818 | Replicon | chromosome |
| Accession | NZ_CP074606 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | DLM99_RS00915 | Protein ID | WP_000533909.1 |
| Coordinates | 197333..197818 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | DLM99_RS00910 | Protein ID | WP_000965886.1 |
| Coordinates | 197058..197345 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DLM99_RS00890 (192463) | 192463..193374 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| DLM99_RS00895 (193384) | 193384..195453 | + | 2070 | WP_001291739.1 | glycine--tRNA ligase subunit beta | - |
| DLM99_RS23840 (195843) | 195843..196241 | + | 399 | Protein_178 | IS3 family transposase | - |
| DLM99_RS00905 (196413) | 196413..196880 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| DLM99_RS00910 (197058) | 197058..197345 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| DLM99_RS00915 (197333) | 197333..197818 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| DLM99_RS00920 (198189) | 198189..198728 | - | 540 | WP_000047147.1 | copper-binding periplasmic metallochaperone CueP | - |
| DLM99_RS00925 (198902) | 198902..199114 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| DLM99_RS00930 (199402) | 199402..199692 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| DLM99_RS00935 (200131) | 200131..200841 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| DLM99_RS00940 (200891) | 200891..201865 | - | 975 | WP_000804669.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| DLM99_RS00945 (202084) | 202084..202746 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T202515 WP_000533909.1 NZ_CP074606:197333-197818 [Salmonella enterica subsp. enterica serovar Newport str.]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T202515 NZ_CP099489:c3795877-3795458 [Ornithinimicrobium sp. HY1793]
GTGGTCCTGACTCAGCCATGGCTGATTGACACGTCTGCGTTCGCGCGGTTGTCGACCTCACCCGACGCGGTGGTCTGGAT
GGAGCGAATCGACCGCGGCCTGGTCCGAGCCGCGACCGTCACGCTGCTCGAGCTGGGATACTCCGCGCGGTCTGGCGCAG
ACTGGACCAACGGGTTCCAGCAGCCTCCGTTGAGTCACGTGCCGGTGGAGAACCTGACTCCAGCCATGGAAGCCCGAGCC
CTGGTGGTGCAGGGACTCCTGGCCGAGCGCGGACATCATCGCGCGGCGAAGGTTCCAGACCTGATCGTTGCGGCCACTGC
AGAGACGGCAGGGCTGACGGTGTTGCACTGCGACAAGGACTTTGACCTCATCGCCGACGTGACGGGGCAACCGGTGGAGA
GGCTGCGCGTCAGCGCCTGA
GTGGTCCTGACTCAGCCATGGCTGATTGACACGTCTGCGTTCGCGCGGTTGTCGACCTCACCCGACGCGGTGGTCTGGAT
GGAGCGAATCGACCGCGGCCTGGTCCGAGCCGCGACCGTCACGCTGCTCGAGCTGGGATACTCCGCGCGGTCTGGCGCAG
ACTGGACCAACGGGTTCCAGCAGCCTCCGTTGAGTCACGTGCCGGTGGAGAACCTGACTCCAGCCATGGAAGCCCGAGCC
CTGGTGGTGCAGGGACTCCTGGCCGAGCGCGGACATCATCGCGCGGCGAAGGTTCCAGACCTGATCGTTGCGGCCACTGC
AGAGACGGCAGGGCTGACGGTGTTGCACTGCGACAAGGACTTTGACCTCATCGCCGACGTGACGGGGCAACCGGTGGAGA
GGCTGCGCGTCAGCGCCTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT202515 WP_000965886.1 NZ_CP074606:197058-197345 [Salmonella enterica subsp. enterica serovar Newport str.]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT202515 NZ_CP099489:c3796086-3795868 [Ornithinimicrobium sp. HY1793]
ATGACCGATGTTCTGATCCGCAATCTGGATGACGAAACGATCCGCCGTGTTGATGCTGATGCGGCGCGGCTCGGGCTGTC
GCGCAACGAGTACCTACGCCGGGCGGTAGCCCGGTTGGGCGGGGCGGCCCGAGCGACGACCCGCGAGGATCTTGATCGGT
TCGCCGATCGGTTCGCCGATCTGAGCGACGAAACGGTCAGGGGAGCCGCGTGGTCCTGA
ATGACCGATGTTCTGATCCGCAATCTGGATGACGAAACGATCCGCCGTGTTGATGCTGATGCGGCGCGGCTCGGGCTGTC
GCGCAACGAGTACCTACGCCGGGCGGTAGCCCGGTTGGGCGGGGCGGCCCGAGCGACGACCCGCGAGGATCTTGATCGGT
TCGCCGATCGGTTCGCCGATCTGAGCGACGAAACGGTCAGGGGAGCCGCGTGGTCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK8 | |
| AlphaFold DB | A0A3V2JDX2 |