Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3991803..3992581 Replicon chromosome
Accession NZ_CP074592
Organism Salmonella bongori serovar 40:z35:- strain CFSAN001045

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag AIT23_RS18865 Protein ID WP_000622308.1
Coordinates 3991803..3992291 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A731NK64
Locus tag AIT23_RS18870 Protein ID WP_063133043.1
Coordinates 3992288..3992581 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AIT23_RS18855 (3990838) 3990838..3991089 + 252 WP_024131240.1 hypothetical protein -
AIT23_RS18860 (3991171) 3991171..3991623 + 453 WP_000434168.1 hypothetical protein -
AIT23_RS18865 (3991803) 3991803..3992291 - 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
AIT23_RS18870 (3992288) 3992288..3992581 - 294 WP_063133043.1 DUF1778 domain-containing protein Antitoxin
AIT23_RS18875 (3992910) 3992910..3993116 - 207 WP_213892519.1 helix-turn-helix transcriptional regulator -
AIT23_RS18880 (3993113) 3993113..3993574 - 462 WP_213892521.1 hypothetical protein -
AIT23_RS18885 (3993946) 3993946..3996462 - 2517 WP_250131633.1 S8 family peptidase -
AIT23_RS18890 (3996440) 3996440..3997480 - 1041 WP_213892522.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3985481..3997480 11999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T202513 WP_000622308.1 NZ_CP074592:c3992291-3991803 [Salmonella bongori serovar 40:z35:-]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T202513 NZ_CP099489:c593531-593202 [Ornithinimicrobium sp. HY1793]
GTGAGGCGTGGCGAGATCTTCACCGCCGCCGCACGCGGTCCCTACACGGGCAAACCGCGCCCCGTCGTCGTCATTCAGGA
CGACCGGTTCGACGCCACGGCATCAGTGACTGTGTGCCCAGTCACGACGAACCCGGTGGAGGCGCCCCTGACACGCCTCA
TGATTCATCCCACGGAGCTGAACGGTCTCGACCAACCGTCCAGGCTGATGGTCGACAAGGTGATGACGATGCCGCGGACC
GGCCTGCGCGAACGCGTGGGTCGCCTGACTGACGGCGACCTGGTGCGTCTCAACCGGGCCTTGATCGTCTTCCTTGGTCT
GGCGGGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10919.53 Da        Isoelectric Point: 8.6141

>AT202513 WP_063133043.1 NZ_CP074592:c3992581-3992288 [Salmonella bongori serovar 40:z35:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLTRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202513 NZ_CP099489:c593749-593528 [Ornithinimicrobium sp. HY1793]
ATGGCATCCACCCAGGACCGCGTGCGTCGTCACCGTGCGAAACTGCGCAGGCAGGGGCTTCGACCGGTTCAGATCTGGGT
GCCCGACGTCAGGGCCCCAGAGTTCACAGCCGAAGCACATCGCCAGGCCGCGGCAATCGCCGCGAGCGAAATGGAGTCTG
AGGACCAAGCCTTCGTCGACGCCATCTCCTGGGAGTGGGACGAGCCGGAGCAGTCTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A731NK64

References