Detailed information of TA system TA202512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3880168..3880811
• Replicon: chromosome
• Accession: NZ_CP074592
• Organism: Salmonella bongori serovar 40:z35:- strain CFSAN001045

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: AIT23_RS18290
• Protein ID: WP_038393599.1
• Coordinates: 3880395..3880811 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B5F3H9
• Locus tag: AIT23_RS18285
• Protein ID: WP_001261294.1
• Coordinates: 3880168..3880398 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AIT23_RS18275 (3877181)	3877181..3879319	+	2139	WP_079774152.1	anaerobic ribonucleoside-triphosphate reductase	-
AIT23_RS18280 (3879536)	3879536..3880000	+	465	WP_079774151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
AIT23_RS18285 (3880168)	3880168..3880398	+	231	WP_001261294.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
AIT23_RS18290 (3880395)	3880395..3880811	+	417	WP_038393599.1	type II toxin-antitoxin system VapC family toxin	Toxin
AIT23_RS18295 (3880872)	3880872..3882785	-	1914	WP_213892485.1	BglG family transcription antiterminator	-
AIT23_RS18300 (3882802)	3882802..3883542	-	741	WP_079772538.1	KDGP aldolase family protein	-
AIT23_RS18305 (3883539)	3883539..3884657	-	1119	WP_079774148.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
AIT23_RS18310 (3884641)	3884641..3885774	-	1134	WP_079774147.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15165.52 Da
• Isoelectric Point: 8.1381

>T202512 WP_038393599.1 NZ_CP074592:3880395-3880811 [Salmonella bongori serovar 40:z35:-]
MSKTYMLDTCICSFIMREQPEAVLKRLEQTVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Nucleotide

• Length: 417 bp

>T202512 NZ_CP099489:451811-452209 [Ornithinimicrobium sp. HY1793]
GTGACGGCGCTGTATGTCGATTCATCCGCCCTGTGCAAGCTGGTGGCGCAGGAGGAGCACACCGCGGCCATGCACCGGCT
CTGGACGACCCATGACGGTGACCTCGTGTCAAGCGACCTGGCGCGCACCGAGGTGATGCGCCAGGCTGGCCGGTGCGACC
CGCCGCGCTCGACCGAGGCCCGGGCTGTGCTGGATGCCTTGGTCCTGGTCCCCGTCCTGACCAGGATCGCGCAGGGGGCA
GGGACGCTTGGGCCGCCCTCCCTGCGCAGTCTGGACGCGTTGCACCTGATGACGGCTCTTGAACTGGGCGACGATCTCGC
GGGTGTCGTCACTTACGACGACCGGCAGGCCGAGGCCGCACGGCACCTTGGACTGCCGGTGGTCACGCCCCGCTCGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8878.90 Da
• Isoelectric Point: 4.6677

>AT202512 WP_001261294.1 NZ_CP074592:3880168-3880398 [Salmonella bongori serovar 40:z35:-]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Nucleotide

• Length: 231 bp

>AT202512 NZ_CP099489:451539-451814 [Ornithinimicrobium sp. HY1793]
ATGTCGAGTGTGGGGATCAGGGAGTTGAGGCAGAGCGCGTCCGCAGTCGTCGCCCGTGCGGCAGCAGGCGAGACCATCAC
GATCACGGACCGGGGGCGACCGGTGGCCCAGATCGGACCACGCACGCCGAACGGGCTGCACGCACTCCGGGAGCAGGGGG
TGGTGCGGGAGCCGCGGGCCTCAGCTGCGGATCTCCCCCTGCCCGCGCCACTGCCCGACGGAGCTCCGAGCCTGGGCCAG
CTCCTGGAGTCTGACCGCGAGGAGCGGCTGACGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V4SIC2