Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3260619..3261239 Replicon chromosome
Accession NZ_CP074592
Organism Salmonella bongori serovar 40:z35:- strain CFSAN001045

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag AIT23_RS15465 Protein ID WP_001280991.1
Coordinates 3261021..3261239 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag AIT23_RS15460 Protein ID WP_000344807.1
Coordinates 3260619..3260993 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AIT23_RS15450 (3255759) 3255759..3256952 + 1194 WP_020842830.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AIT23_RS15455 (3256975) 3256975..3260124 + 3150 WP_001132513.1 efflux RND transporter permease AcrB -
AIT23_RS15460 (3260619) 3260619..3260993 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
AIT23_RS15465 (3261021) 3261021..3261239 + 219 WP_001280991.1 HHA domain-containing protein Toxin
AIT23_RS15470 (3261417) 3261417..3261968 + 552 WP_001278796.1 maltose O-acetyltransferase -
AIT23_RS15475 (3262085) 3262085..3262555 + 471 WP_079772190.1 YlaC family protein -
AIT23_RS15480 (3262608) 3262608..3262748 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
AIT23_RS15485 (3262754) 3262754..3263014 - 261 WP_000801419.1 type B 50S ribosomal protein L31 -
AIT23_RS15490 (3263218) 3263218..3264768 + 1551 WP_020842828.1 EAL domain-containing protein -
AIT23_RS15500 (3265007) 3265007..3265396 + 390 WP_000908589.1 MGMT family protein -
AIT23_RS15505 (3265429) 3265429..3265998 - 570 WP_000779806.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202511 WP_001280991.1 NZ_CP074592:3261021-3261239 [Salmonella bongori serovar 40:z35:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202511 NZ_CP099481:496998-497282 [Companilactobacillus allii]
ATGCTTGAGATTGTTCAGACCCCAACATTTGTAAAAGATTTTAAAAAATTGAAAAAGAAACATTATAATATGCTTCTACT
AAAAAAAGTAGTTACTCATATTGTAAAAGGTGAAAATGAAATATTAGTTTCAAAATATCGTGATCATGCGCTAAAAGGTA
ATTGGCAAGGATTTAGAGAAGTACATATCGAAAAGGATTGGTTATTAGTTTATTTGGTAAATAAGGGAGAGTTAAGACTG
GCCTTAATTAGAACTGGTTCCCACAGTCAAATATTAGGAAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202511 WP_000344807.1 NZ_CP074592:3260619-3260993 [Salmonella bongori serovar 40:z35:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202511 NZ_CP099481:496751-497005 [Companilactobacillus allii]
ATGTCTGATACCAGAATTAGTTTACGAATTGATCCGGAATTAAAAAAGGATGCACAAGAGCTATACAGTGACTTAGGTTT
GGATTTAACTTCAGCTGTAACAATGTTCTTGAAACAGTCAGTAAGAGAACAGGCGTTGCCATTTAAACCGGAATTGGAAG
ATTCCGAGAGTGTACAGGCTAGAAAAGAAGCGTTCAAAAAAGATTTAAAGAAGTATAAAACAGTTGATGATTGGTGGGAT
AATCTTAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References