Detailed information of TA system TA202510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2307519..2308261
• Replicon: chromosome
• Accession: NZ_CP074592
• Organism: Salmonella bongori serovar 40:z35:- strain CFSAN001045

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: AIT23_RS10980
• Protein ID: WP_079773965.1
• Coordinates: 2307773..2308261 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: S5MPV7
• Locus tag: AIT23_RS10975
• Protein ID: WP_020844238.1
• Coordinates: 2307519..2307785 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AIT23_RS10965 (2302753)	2302753..2305281	+	2529	WP_213892085.1	malto-oligosyltrehalose synthase	-
AIT23_RS10970 (2305324)	2305324..2307399	+	2076	WP_079773966.1	glycogen debranching protein GlgX	-
AIT23_RS10975 (2307519)	2307519..2307785	+	267	WP_020844238.1	DUF1778 domain-containing protein	Antitoxin
AIT23_RS10980 (2307773)	2307773..2308261	+	489	WP_079773965.1	GNAT family N-acetyltransferase	Toxin
AIT23_RS10985 (2308829)	2308829..2309218	+	390	WP_015702869.1	RidA family protein	-
AIT23_RS10990 (2309240)	2309240..2309368	+	129	Protein_2163	RidA family protein	-
AIT23_RS10995 (2309449)	2309449..2310516	-	1068	WP_079794120.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
AIT23_RS11000 (2310693)	2310693..2311181	-	489	WP_079772898.1	MarR family winged helix-turn-helix transcriptional regulator	-
AIT23_RS11005 (2311226)	2311226..2312734	+	1509	WP_213892086.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (33-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17749.56 Da
• Isoelectric Point: 9.5852

>T202510 WP_079773965.1 NZ_CP074592:2307773-2308261 [Salmonella bongori serovar 40:z35:-]
VGKVTAPAPLSTLHNLAEFCCGEGLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEAMGSLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Nucleotide

• Length: 489 bp

>T202510 NZ_CP099476:42092-42508 [Roseomonas mucosa]
ATGCTGCGCTATCTGCTGGACACGAATCTCTGCATCCGTGTTCTGCGAGATCGACCGCAAGGCCTACGAACACGCTTCAA
CGCCGAGGCCGGCTCACTCTGCATCTCGACCGTGGTTCTGATGGAGTTACTGCACGGTGCGGGCAAGTCGGCCCGCCCGA
TCGAGAACCGGCGGGAGGTGGAGCGCTTCACGGCGCGGCTGGATGTGCTGGCCTTCGACGCGGACGCAGCAGCGCATGCG
GGAGAGATTCGCACAGCGCTGGAGCGCGCCGGGCAGGTTATTGGTGCCTACGATCTGATGATCGCGGGACACGCGCGTAG
CCGCGGGCTGGTCGTGGTCACAGGCAACCTCAGCGAGTTCCGCCGCGTGGAGGGACTACGCTGTGAGGACTGGCTGGCGT
CAGTGCAGGAAAAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9999.47 Da
• Isoelectric Point: 4.7961

>AT202510 WP_020844238.1 NZ_CP074592:2307519-2307785 [Salmonella bongori serovar 40:z35:-]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Nucleotide

• Length: 267 bp

>AT202510 NZ_CP099476:41871-42092 [Roseomonas mucosa]
ATGACCCGGACCACTCTCTTTCAGAGCAACCGGACGCAGGCCGTACGTCTGCCGAAGGGCGTGGCCTTTCCAGAAAGTGT
TAGGGAAGTCTCGATCCTCCGGGACGGCACCCGCCGGGTCATCGTGCCGGCGGATGCTAGTTGGGACGACTTCTTCGGTG
CACCCGGGATTGACCTGCCGGACCGCAACCAGCCTCGTGCCGAGGAACGCGAGCGCTTCTGA

Structures

Antitoxin

• AlphaFold DB: S5MPV7