Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 803139..803799 Replicon chromosome
Accession NZ_CP074592
Organism Salmonella bongori serovar 40:z35:- strain CFSAN001045

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag AIT23_RS03875 Protein ID WP_000244759.1
Coordinates 803386..803799 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag AIT23_RS03870 Protein ID WP_000351186.1
Coordinates 803139..803405 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AIT23_RS03850 (799136) 799136..800569 - 1434 WP_079774384.1 6-phospho-beta-glucosidase -
AIT23_RS03855 (800727) 800727..801038 + 312 WP_079773282.1 N(4)-acetylcytidine aminohydrolase -
AIT23_RS03860 (801202) 801202..801861 + 660 WP_024143399.1 hemolysin III family protein -
AIT23_RS03865 (801912) 801912..802892 - 981 WP_213892862.1 tRNA-modifying protein YgfZ -
AIT23_RS03870 (803139) 803139..803405 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
AIT23_RS03875 (803386) 803386..803799 + 414 WP_000244759.1 protein YgfX Toxin
AIT23_RS03880 (803851) 803851..804372 - 522 WP_001055887.1 flavodoxin FldB -
AIT23_RS03885 (804485) 804485..805381 + 897 WP_079774386.1 site-specific tyrosine recombinase XerD -
AIT23_RS03890 (805405) 805405..806118 + 714 WP_079773249.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AIT23_RS03895 (806124) 806124..807857 + 1734 WP_038392510.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T202501 WP_000244759.1 NZ_CP074592:803386-803799 [Salmonella bongori serovar 40:z35:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T202501 NZ_CP099464:c5230410-5230150 [Dolichospermum heterosporum TAC447]
ATGAGTAGAATGTTGGCTTGGACTGATGAGGCTTGGGGTAATTATCTTTACTGGCAAGGGCAAGACAAAAAGACTCTCAA
AAGAATCAATAAGTTGATTGAGGAGACGATGCGGATGCCTTTTGAGGGTATTGGTAAACCAGAGCCTCTCAAGGAAAATT
TAGCCGGATTTTGGTCACGGCGAATTGATGATACAAATCGTTTGGTTTATGCTGTTGATGATGTCTATGTAACTATTATT
TCTTGCCGATATCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT202501 WP_000351186.1 NZ_CP074592:803139-803405 [Salmonella bongori serovar 40:z35:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202501 NZ_CP099464:c5230657-5230403 [Dolichospermum heterosporum TAC447]
ATGAAAATTATCTCTTTTAGCGAGGCCAGAAATAGTCTGAAAACGGTTTTAGACCAGGTGACGGAAGATGCCGACTATAC
AATTATCACTAGACGGGATGCTGATGATACGGTGGTGATGTCCCTGGAGTTTTTTAATAGTCTCATGGAGACTGTGCATT
TATTGAAGTCTCCGGCAAATGCAGCCCATTTAGAACGTTCCATTGCTCAATTTAAGCAGGGGAAAGTGGTGCAGCGAGAT
TTGTTAAATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References