Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 3840727..3841388 Replicon chromosome
Accession NZ_CP074584
Organism Enterobacter asburiae strain L1 delta-T1RM

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KIJ47_RS18255 Protein ID WP_029740768.1
Coordinates 3840727..3841125 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KIJ47_RS18260 Protein ID WP_029740767.1
Coordinates 3841122..3841388 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIJ47_RS18225 (KIJ47_18220) 3836463..3836693 - 231 WP_155249580.1 hypothetical protein -
KIJ47_RS18230 (KIJ47_18225) 3836784..3837239 - 456 WP_029740773.1 hypothetical protein -
KIJ47_RS18235 (KIJ47_18230) 3837543..3837791 - 249 WP_029740772.1 hypothetical protein -
KIJ47_RS18240 (KIJ47_18235) 3837904..3838857 - 954 WP_029740771.1 helix-turn-helix domain-containing protein -
KIJ47_RS18245 (KIJ47_18240) 3838884..3839663 - 780 WP_029740770.1 MBL fold metallo-hydrolase -
KIJ47_RS18250 (KIJ47_18245) 3839786..3840586 - 801 WP_029740769.1 lipoprotein NlpA -
KIJ47_RS18255 (KIJ47_18250) 3840727..3841125 - 399 WP_029740768.1 type II toxin-antitoxin system VapC family toxin Toxin
KIJ47_RS18260 (KIJ47_18255) 3841122..3841388 - 267 WP_029740767.1 virulence protein Antitoxin
KIJ47_RS18265 (KIJ47_18260) 3841518..3841937 - 420 WP_029740766.1 GNAT family N-acetyltransferase -
KIJ47_RS18270 (KIJ47_18265) 3842124..3842693 + 570 WP_029740765.1 helix-turn-helix domain-containing protein -
KIJ47_RS18275 (KIJ47_18270) 3842842..3843963 + 1122 WP_029740764.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14948.13 Da        Isoelectric Point: 6.4785

>T202492 WP_029740768.1 NZ_CP074584:c3841125-3840727 [Enterobacter asburiae]
MRHMLDTNIVSHLFKRHPEVISRMTCLTPGDVCISSITEAELLYGADKKKSSRLKETIQEFLNTITICDWDSEAAATYGE
LRAAMEKRGKVMGDLDQLIAAHAISRRTTIVTNDRAFRMVQELTVEDWTTTS

Download         Length: 399 bp

>T202492 NZ_CP099464:2663818-2664003 [Dolichospermum heterosporum TAC447]
TTGATTGATTTAACTCCTGAATATCAGAGAAATTTAAAACATTTAGCCAAAAAATACCGAAATATTCGTTCTGATACTCA
ATCTTTCATTACAGAATTGCAAAAAGGAAATTTATTAGGAGATAGATTAACTGGTTTTAATGAAGATGTTTATATTTATA
AAGCTAGAGTCAAAAATAGTAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10028.34 Da        Isoelectric Point: 5.8481

>AT202492 WP_029740767.1 NZ_CP074584:c3841388-3841122 [Enterobacter asburiae]
MERTAKLFKKGRHQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVQTKSWDTFFRMLSVTDVPDSFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp

>AT202492 NZ_CP099464:2663555-2663800 [Dolichospermum heterosporum TAC447]
ATGAAAGCTTTTGAAGTCATGGGAAAAGTTGATGAAAAAGGTCAATTATTATTAGATAAACCTTTAGAAATTTATACATC
TAGTCAAGTGAGAGTAATTATCCTTGTATCAGATGACATTGAATCTGATCCTGATGATACTCCAATTCAGGAAATAAAAG
AGAGTTTAAAAACAGCATTACAAGAAGCAAAAGCAGGAAAAAGAATCCCTTTGGAAAAAATGTGGGAAGGAATTGATGCA
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References