Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2850097..2850717 Replicon chromosome
Accession NZ_CP074584
Organism Enterobacter asburiae strain L1 delta-T1RM

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag KIJ47_RS13535 Protein ID WP_008499287.1
Coordinates 2850499..2850717 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag KIJ47_RS13530 Protein ID WP_008499288.1
Coordinates 2850097..2850471 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIJ47_RS13520 (KIJ47_13515) 2845224..2846417 + 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KIJ47_RS13525 (KIJ47_13520) 2846440..2849586 + 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
KIJ47_RS13530 (KIJ47_13525) 2850097..2850471 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
KIJ47_RS13535 (KIJ47_13530) 2850499..2850717 + 219 WP_008499287.1 HHA domain-containing protein Toxin
KIJ47_RS13540 (KIJ47_13535) 2850923..2851474 + 552 WP_023310599.1 maltose O-acetyltransferase -
KIJ47_RS13545 (KIJ47_13540) 2851592..2852059 + 468 WP_029741965.1 YlaC family protein -
KIJ47_RS13550 (KIJ47_13545) 2852031..2853491 - 1461 WP_029741966.1 PLP-dependent aminotransferase family protein -
KIJ47_RS13555 (KIJ47_13550) 2853593..2854303 + 711 WP_023310596.1 GNAT family protein -
KIJ47_RS13560 (KIJ47_13555) 2854300..2854440 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KIJ47_RS13565 (KIJ47_13560) 2854443..2854703 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T202490 WP_008499287.1 NZ_CP074584:2850499-2850717 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T202490 NZ_CP099464:c1920664-1920401 [Dolichospermum heterosporum TAC447]
ATGATGGAATTTGAATTTGATGCAAACAAAAGTGCAACAAATAAAACTAAACATAACATTGATTTTATTGAAGCACAAAA
ACTTTGGAGAGATACGCATCTAGTAGAAGTCCCCGCAAACACAACCGATGAACCCAGATTTTTAGTTATTGGCAAGATAG
CTGATAAACATTGGTCAGCAGTCATTACCTATCGTAGTGATAAAATAAGAATTATTTCTGTTCGTCGTTCTCGTACTGAA
GAGGCCAATATTTATGAAAGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT202490 WP_008499288.1 NZ_CP074584:2850097-2850471 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT202490 NZ_CP099464:c1920411-1920178 [Dolichospermum heterosporum TAC447]
ATGAAAGCTGAAGAATTTGATACTAAGTTTGATAATGGTGAAGATATTACTGAGTTGTTAGACTTATCTCAAGTACATCA
TCCAAGGTATACACAAAAAAGAGTTAATATTGATTTTCCTGTTTGGATGATAGAAGCTTTAGAACAGGAAGCAAAACGTT
TAGGCGTGACTTCTGATTCTATTATTAAATTGTGGCTTGCTGAACGTCTGGATAAAAAAGTGATTACCAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References