Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 169343..170000 Replicon chromosome
Accession NZ_CP074584
Organism Enterobacter asburiae strain L1 delta-T1RM

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KIJ47_RS00890 Protein ID WP_021242050.1
Coordinates 169590..170000 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag KIJ47_RS00885 Protein ID WP_010435322.1
Coordinates 169343..169609 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIJ47_RS00860 (KIJ47_00860) 164524..165957 - 1434 WP_029739205.1 6-phospho-beta-glucosidase BglA -
KIJ47_RS00865 (KIJ47_00865) 166074..166805 - 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
KIJ47_RS00870 (KIJ47_00870) 166857..167168 + 312 WP_029739203.1 N(4)-acetylcytidine aminohydrolase -
KIJ47_RS00875 (KIJ47_00875) 167334..167993 + 660 WP_023309101.1 hemolysin III family protein -
KIJ47_RS00880 (KIJ47_00880) 168068..169048 - 981 WP_029739202.1 tRNA-modifying protein YgfZ -
KIJ47_RS00885 (KIJ47_00885) 169343..169609 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
KIJ47_RS00890 (KIJ47_00890) 169590..170000 + 411 WP_021242050.1 protein YgfX Toxin
KIJ47_RS00895 (KIJ47_00895) 170007..170528 - 522 WP_023309099.1 flavodoxin FldB -
KIJ47_RS00900 (KIJ47_00900) 170630..171526 + 897 WP_023333303.1 site-specific tyrosine recombinase XerD -
KIJ47_RS00905 (KIJ47_00905) 171555..172268 + 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KIJ47_RS00910 (KIJ47_00910) 172274..174007 + 1734 WP_029740339.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T202479 WP_021242050.1 NZ_CP074584:169590-170000 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T202479 NZ_CP099415:149104-149253 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT202479 WP_010435322.1 NZ_CP074584:169343-169609 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202479 NZ_CP099415:c149059-149000 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References