Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3709240..3709897 Replicon chromosome
Accession NZ_CP074580
Organism Klebsiella pneumoniae strain B30155

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KH752_RS17855 Protein ID WP_002916310.1
Coordinates 3709487..3709897 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KH752_RS17850 Protein ID WP_002916312.1
Coordinates 3709240..3709506 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH752_RS17825 (KH752_17825) 3704396..3705829 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KH752_RS17830 (KH752_17830) 3705948..3706676 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KH752_RS17835 (KH752_17835) 3706726..3707037 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KH752_RS17840 (KH752_17840) 3707201..3707860 + 660 WP_004889817.1 hemolysin III family protein -
KH752_RS17845 (KH752_17845) 3708011..3708994 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KH752_RS17850 (KH752_17850) 3709240..3709506 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KH752_RS17855 (KH752_17855) 3709487..3709897 + 411 WP_002916310.1 protein YgfX Toxin
KH752_RS17860 (KH752_17860) 3709904..3710425 - 522 WP_004144730.1 flavodoxin FldB -
KH752_RS17865 (KH752_17865) 3710526..3711422 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KH752_RS17870 (KH752_17870) 3711445..3712158 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KH752_RS17875 (KH752_17875) 3712164..3713897 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202468 WP_002916310.1 NZ_CP074580:3709487-3709897 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202468 NZ_CP099413:2011445-2011547 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202468 WP_002916312.1 NZ_CP074580:3709240-3709506 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202468 NZ_CP099413:c2011554-2011409 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References