Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2376529..2377045 Replicon chromosome
Accession NZ_CP074580
Organism Klebsiella pneumoniae strain B30155

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag KH752_RS11355 Protein ID WP_004894697.1
Coordinates 2376529..2376813 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KH752_RS11360 Protein ID WP_002886901.1
Coordinates 2376803..2377045 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH752_RS11330 (KH752_11330) 2371924..2372187 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
KH752_RS11335 (KH752_11335) 2372317..2372490 + 174 WP_002886906.1 hypothetical protein -
KH752_RS11340 (KH752_11340) 2372493..2373236 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
KH752_RS11345 (KH752_11345) 2373594..2375732 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
KH752_RS11350 (KH752_11350) 2376061..2376525 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KH752_RS11355 (KH752_11355) 2376529..2376813 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KH752_RS11360 (KH752_11360) 2376803..2377045 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KH752_RS11365 (KH752_11365) 2377123..2379033 - 1911 WP_023325426.1 PRD domain-containing protein -
KH752_RS11370 (KH752_11370) 2379056..2380210 - 1155 WP_004178372.1 lactonase family protein -
KH752_RS11375 (KH752_11375) 2380277..2381017 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T202463 WP_004894697.1 NZ_CP074580:c2376813-2376529 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202463 NZ_CP099402:c840265-839972 [Rhizobium sp. Pop5]
GTGAAGCTCACCTGGTCTGCGTTCGTGTTATCGGATCGCGACGCCATCTTCACATACATAGAAGCAGAAAATCCGTCAGC
CGCCATTCTGGTCGACGAACGGATCGCTGCTGCCGTCCGTCGGTTGATAGATTTTCCAGCGAGCGGCCGTGTTGGCAGAA
TCGCTGGCACCCGAGAACTGGTGATCAACGGCACGCCCTACGTCGCGGCGTATTCATTTAATGAAACAGCGGTCCGAATT
CTTCGCGTTCTCCACGGTGCGCAGGAATGGCCAGATACTTTGCCAACGGGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202463 WP_002886901.1 NZ_CP074580:c2377045-2376803 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202463 NZ_CP099402:c840570-840262 [Rhizobium sp. Pop5]
ATGGCTGCAAATGCACTGGTACAAACTCGTATTGACGCCGAGATTCGGGATCGTGCCTCCGCAGTGCTTGGAAATATGGG
GCTTACGGTATCGGACGCGGTTCGTATCTTGCTCACCCGGACAGCCAACGAGGGTGCGCTGCCACTGGAGCTTCTTTCAG
GCAGCGAGGCCCATGACGCTTGGTTTCGCGCCAAGGTACTTGAAGCGCTGAACGATACGCGACCGGACGTTTCGGACGAT
GAAGTCGAGACCCATTTTGCTGAACGTAGAGCGGCCGCTCGCCTTAACGCGGGCGCGCGCAAATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References