Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 968681..969315 | Replicon | chromosome |
Accession | NZ_CP074578 | ||
Organism | Pseudomonas syringae strain Susan2139 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A193SM35 |
Locus tag | KIJ28_RS04320 | Protein ID | WP_003345997.1 |
Coordinates | 968681..969085 (-) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A3M4XXE1 |
Locus tag | KIJ28_RS04325 | Protein ID | WP_003345999.1 |
Coordinates | 969085..969315 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KIJ28_RS04290 (KIJ28_04290) | 964465..964947 | + | 483 | WP_003345989.1 | PAS domain-containing protein | - |
KIJ28_RS04295 (KIJ28_04295) | 965044..966300 | + | 1257 | WP_004402530.1 | 3-phosphoshikimate 1-carboxyvinyltransferase | - |
KIJ28_RS04300 (KIJ28_04300) | 966323..966985 | - | 663 | WP_003408532.1 | ChrR family anti-sigma-E factor | - |
KIJ28_RS04305 (KIJ28_04305) | 966985..967497 | - | 513 | WP_213632060.1 | sigma-70 family RNA polymerase sigma factor | - |
KIJ28_RS04310 (KIJ28_04310) | 967733..967921 | - | 189 | WP_024663313.1 | hypothetical protein | - |
KIJ28_RS04315 (KIJ28_04315) | 968273..968494 | + | 222 | WP_003345996.1 | hypothetical protein | - |
KIJ28_RS04320 (KIJ28_04320) | 968681..969085 | - | 405 | WP_003345997.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
KIJ28_RS04325 (KIJ28_04325) | 969085..969315 | - | 231 | WP_003345999.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
KIJ28_RS04330 (KIJ28_04330) | 969432..970313 | - | 882 | WP_213631580.1 | aldose 1-epimerase | - |
KIJ28_RS04335 (KIJ28_04335) | 970288..971259 | - | 972 | WP_213631581.1 | DMT family transporter | - |
KIJ28_RS04340 (KIJ28_04340) | 971344..972624 | - | 1281 | WP_003421655.1 | TRAP transporter large permease | - |
KIJ28_RS04345 (KIJ28_04345) | 972625..973152 | - | 528 | WP_003408544.1 | TRAP transporter small permease | - |
KIJ28_RS04350 (KIJ28_04350) | 973216..974241 | - | 1026 | WP_010424887.1 | TRAP transporter substrate-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14946.21 Da Isoelectric Point: 6.8620
>T202455 WP_003345997.1 NZ_CP074578:c969085-968681 [Pseudomonas syringae]
MLKYMLDTNICIFTIKNKPTSVREAFNLHHGQLCISAITLMELVYGAEKSLSPERNLAVVEGFTARLEVLPYDSDAAAHT
GMIRAELARSGTPIGPYDQMIAGHARSLGLVVITNNQREFRRVEGLRVEDWVSQ
MLKYMLDTNICIFTIKNKPTSVREAFNLHHGQLCISAITLMELVYGAEKSLSPERNLAVVEGFTARLEVLPYDSDAAAHT
GMIRAELARSGTPIGPYDQMIAGHARSLGLVVITNNQREFRRVEGLRVEDWVSQ
Download Length: 405 bp
>T202455 NZ_CP099397:4253345-4253764 [Pseudomonas hydrolytica]
ATGATCCTGCTTGATACCAACGTGCTGTCGGAACTCATGCGTGCCAAGCCTGCGCCTCAGGTTCTGGAGTGGGTTGACGC
TCAGCCTGTCGGGGATCTGGTAATCACCTCGATCACCGTTGCGGAAATTCTCTATGGCATTGCCAGGATGCCGGACGGGA
AACGCAAGCAGGGACTGCTCGATGTAGCCTCGGTCATGTTCGATGAAGACTTCGCGGGCAATATCCTGCCGTTCGATGCA
GATGCCGCTGTGCATTACGCAGAGATAGCCGCAGAAACCGAGGCTAAAGGGCGGGTGGTTGATATGGCCGATGCGCAGAT
CGCTGCAATCGGTCGGCTACATGATGCCGTGATCGCAACTCGCAATATTCGCCACTTCGAAACGCTAGGCGTTGCCCTGG
TAGATCCCTGGAGCAATTAG
ATGATCCTGCTTGATACCAACGTGCTGTCGGAACTCATGCGTGCCAAGCCTGCGCCTCAGGTTCTGGAGTGGGTTGACGC
TCAGCCTGTCGGGGATCTGGTAATCACCTCGATCACCGTTGCGGAAATTCTCTATGGCATTGCCAGGATGCCGGACGGGA
AACGCAAGCAGGGACTGCTCGATGTAGCCTCGGTCATGTTCGATGAAGACTTCGCGGGCAATATCCTGCCGTTCGATGCA
GATGCCGCTGTGCATTACGCAGAGATAGCCGCAGAAACCGAGGCTAAAGGGCGGGTGGTTGATATGGCCGATGCGCAGAT
CGCTGCAATCGGTCGGCTACATGATGCCGTGATCGCAACTCGCAATATTCGCCACTTCGAAACGCTAGGCGTTGCCCTGG
TAGATCCCTGGAGCAATTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8580.59 Da Isoelectric Point: 4.5557
>AT202455 WP_003345999.1 NZ_CP074578:c969315-969085 [Pseudomonas syringae]
MEQSTVFKSNRSQAVRLPKAVALPDDVKRVDVVAVGRTRIISPAGEMWNSWFDGESVSDDFMAEREQPAEQQRESL
MEQSTVFKSNRSQAVRLPKAVALPDDVKRVDVVAVGRTRIISPAGEMWNSWFDGESVSDDFMAEREQPAEQQRESL
Download Length: 231 bp
>AT202455 NZ_CP099397:4253103-4253348 [Pseudomonas hydrolytica]
ATGGCCGCTATCACTATTCGAAACCTCGACGACGACTTGAAAGCCCAGCTGCGTATTGTCGCGGCTAGCCACGGTCGCTC
CATGGAAGAAGAGGTCCGGTTCATCATTCGGCAGGCTCTGTCACGTCAAGAAAAGCGTGGCGGCTTGGGCAGTCGTATTC
ACTCCCGCTTTGCCGCTGTCGGTGGGGCTGACCTTGAGCTGCCAGAACGCAAAACCAAAGCCCGAGCCGCGAGCTTTGAT
GAATGA
ATGGCCGCTATCACTATTCGAAACCTCGACGACGACTTGAAAGCCCAGCTGCGTATTGTCGCGGCTAGCCACGGTCGCTC
CATGGAAGAAGAGGTCCGGTTCATCATTCGGCAGGCTCTGTCACGTCAAGAAAAGCGTGGCGGCTTGGGCAGTCGTATTC
ACTCCCGCTTTGCCGCTGTCGGTGGGGCTGACCTTGAGCTGCCAGAACGCAAAACCAAAGCCCGAGCCGCGAGCTTTGAT
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A193SM35 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3M4XXE1 |