Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 4737163..4737758 | Replicon | chromosome |
| Accession | NZ_CP074576 | ||
| Organism | Escherichia coli strain CS18F | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | D6JG31 |
| Locus tag | KHZ70_RS22825 | Protein ID | WP_000155159.1 |
| Coordinates | 4737381..4737758 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | D6JG32 |
| Locus tag | KHZ70_RS22820 | Protein ID | WP_000557315.1 |
| Coordinates | 4737163..4737384 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KHZ70_RS22795 (4732239) | 4732239..4733348 | + | 1110 | WP_001318085.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
| KHZ70_RS22800 (4733396) | 4733396..4734322 | + | 927 | WP_000003010.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| KHZ70_RS22805 (4734319) | 4734319..4735596 | + | 1278 | WP_000803825.1 | branched chain amino acid ABC transporter permease LivM | - |
| KHZ70_RS22810 (4735593) | 4735593..4736360 | + | 768 | WP_000082101.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| KHZ70_RS22815 (4736362) | 4736362..4737075 | + | 714 | WP_000416895.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| KHZ70_RS22820 (4737163) | 4737163..4737384 | + | 222 | WP_000557315.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KHZ70_RS22825 (4737381) | 4737381..4737758 | + | 378 | WP_000155159.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| KHZ70_RS22830 (4737967) | 4737967..4739283 | + | 1317 | WP_000803191.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| KHZ70_RS22835 (4739459) | 4739459..4740346 | + | 888 | WP_121865530.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| KHZ70_RS22840 (4740343) | 4740343..4741188 | + | 846 | WP_000572164.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| KHZ70_RS22845 (4741190) | 4741190..4742260 | + | 1071 | WP_000907828.1 | sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4734319..4743000 | 8681 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13964.25 Da Isoelectric Point: 6.7263
>T202443 WP_000155159.1 NZ_CP074576:4737381-4737758 [Escherichia coli]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT
Download Length: 378 bp
>T202443 NZ_CP099390:4969283-4969594 [Citrobacter braakii]
ATGCATGTTATCAGCCGAAAACCTTTCAACGAGGCAATACTCCGTTTTCCAAACCACATGGCAGCACTCGTTGATTTGCT
GAATATTTTAGAGAAAAAAATGTTCCACACTCCTGAAGAGATGAAGCAGTGCATACCTTCACTGGATAATTTTAAATACA
GAAATAAATGGTGGGTGATTAATGTTTCAGGTAACTGCTTGAGACTTATTGCCTATATTGATTTCAAACTGCAAAAGGTA
TTTGTGAAGCATATCGTTCACCATGCCGAGTATGACAGACTAACCACATACTATCGGGGTCACAAAGAATGA
ATGCATGTTATCAGCCGAAAACCTTTCAACGAGGCAATACTCCGTTTTCCAAACCACATGGCAGCACTCGTTGATTTGCT
GAATATTTTAGAGAAAAAAATGTTCCACACTCCTGAAGAGATGAAGCAGTGCATACCTTCACTGGATAATTTTAAATACA
GAAATAAATGGTGGGTGATTAATGTTTCAGGTAACTGCTTGAGACTTATTGCCTATATTGATTTCAAACTGCAAAAGGTA
TTTGTGAAGCATATCGTTCACCATGCCGAGTATGACAGACTAACCACATACTATCGGGGTCACAAAGAATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8103.24 Da Isoelectric Point: 6.2168
>AT202443 WP_000557315.1 NZ_CP074576:4737163-4737384 [Escherichia coli]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK
Download Length: 222 bp
>AT202443 NZ_CP099390:4969591-4970043 [Citrobacter braakii]
ATGAGAACGCATGAAAGCCATCAGATAGACACAGCCAGTGTAAAATTGATGATTGATACCTTTACCGATGCAGTGAAAAA
AATCCCCCTGTTAGGCAAAGAACAAAATGAGGCAGAGTACCGAAAAGCACTCGCTTTGGTGGAGTTTCTGGTTGATCGTA
ACGACCTGGAAAACCCGTTGTTTGAGCTGCTTTCAGCTCGGATCCGCGACTACGAAAAACATGCACCTGAGTTCAGTGCC
CTCAACCAACAACTGGAACATACTCCTCATGGCGTTGCGTTACTGCGTACGCTCATGGATCAATATGGTCTCAAAGCAGC
AGATCTTGCCAACGAACTTGGTTCAAAATCCAATGTCAGCAACATCTTGAATGGTCGCAGAGCACTGACTGTAAGTCATA
TTAAAATGCTCGCAGAACGCTTTAACCTTCCGGCAGACGCATTCATCGAGTAA
ATGAGAACGCATGAAAGCCATCAGATAGACACAGCCAGTGTAAAATTGATGATTGATACCTTTACCGATGCAGTGAAAAA
AATCCCCCTGTTAGGCAAAGAACAAAATGAGGCAGAGTACCGAAAAGCACTCGCTTTGGTGGAGTTTCTGGTTGATCGTA
ACGACCTGGAAAACCCGTTGTTTGAGCTGCTTTCAGCTCGGATCCGCGACTACGAAAAACATGCACCTGAGTTCAGTGCC
CTCAACCAACAACTGGAACATACTCCTCATGGCGTTGCGTTACTGCGTACGCTCATGGATCAATATGGTCTCAAAGCAGC
AGATCTTGCCAACGAACTTGGTTCAAAATCCAATGTCAGCAACATCTTGAATGGTCGCAGAGCACTGACTGTAAGTCATA
TTAAAATGCTCGCAGAACGCTTTAACCTTCCGGCAGACGCATTCATCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|