Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3933189..3934024 Replicon chromosome
Accession NZ_CP074576
Organism Escherichia coli strain CS18F

Toxin (Protein)


Gene name yeeV Uniprot ID F4TIK8
Locus tag KHZ70_RS19135 Protein ID WP_000854694.1
Coordinates 3933647..3934024 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TIK7
Locus tag KHZ70_RS19130 Protein ID WP_001285605.1
Coordinates 3933189..3933557 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHZ70_RS19090 (3928340) 3928340..3928687 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
KHZ70_RS19095 (3928736) 3928736..3930274 + 1539 WP_000099202.1 IS66-like element ISEc22 family transposase -
KHZ70_RS19100 (3930423) 3930423..3930656 + 234 WP_040235235.1 DUF905 family protein -
KHZ70_RS19105 (3930746) 3930746..3931564 + 819 WP_001175153.1 DUF932 domain-containing protein -
KHZ70_RS19110 (3931830) 3931830..3932309 + 480 WP_001696591.1 antirestriction protein -
KHZ70_RS19115 (3932325) 3932325..3932801 + 477 WP_001696592.1 RadC family protein -
KHZ70_RS24985 (3932888) 3932888..3933109 + 222 Protein_3766 DUF987 domain-containing protein -
KHZ70_RS19130 (3933189) 3933189..3933557 + 369 WP_001285605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KHZ70_RS19135 (3933647) 3933647..3934024 + 378 WP_000854694.1 TA system toxin CbtA family protein Toxin
KHZ70_RS19140 (3934021) 3934021..3934188 + 168 Protein_3769 DUF5983 family protein -
KHZ70_RS19145 (3934246) 3934246..3934443 + 198 WP_086795284.1 DUF957 domain-containing protein -
KHZ70_RS19150 (3934528) 3934528..3935370 + 843 WP_021572009.1 DUF4942 domain-containing protein -
KHZ70_RS19155 (3936119) 3936119..3937657 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14008.02 Da        Isoelectric Point: 7.7293

>T202436 WP_000854694.1 NZ_CP074576:3933647-3934024 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T202436 NZ_CP099390:43316-43657 [Citrobacter braakii]
ATGTGGGAAGTGGAAACAACGGATGTTTTCGATAAATGGTTTGACGTACAGACCGAGGCGCTCAAGGAAGATATGCTCGC
AGCGATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGCAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTGCAGCATCAGGGCAACCCGATTCGGGCGTTCTTCGTGTTTGATCCTTCTCGCCATGGCATC
GTGTTATGCGCTGGCGACAAAACAGGGTTAAACGAGAAGAAATTCTATAAAGAGATGATCAGGCTTGCTGACGCTGAGTA
CCGAAATCACCTTAATAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.48 Da        Isoelectric Point: 6.0601

>AT202436 WP_001285605.1 NZ_CP074576:3933189-3933557 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT202436 NZ_CP099390:43666-43965 [Citrobacter braakii]
ATGGCGACGCTTAAAGAATTGATGGCGAAACAAAGCCCGGAAAGCCAGGAGCGCATTGCTGAAAAAGTAGAAGTGCTACG
TCAGGTGATTGCGTTAAATATGTTACGGGAAGAACTGAATCTCTCTCAGGCGGAACTTGCCTCGGCAATGGGCGTTAAGC
AGCCAACAATCGCAAAAATGGAACAGGCGGATAACGATCCTCGTCTGTCGACGCTTAAGCGTTATGTCACGGCGTTAGGT
GGCGAATTGAGCATTGATGTTAAGTTACCGACAGGTAAAAGAGTCGCGTTTCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2F934

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2V3N6

References