Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 323461..324262 | Replicon | chromosome |
| Accession | NZ_CP074576 | ||
| Organism | Escherichia coli strain CS18F | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D8EBK0 |
| Locus tag | KHZ70_RS01555 | Protein ID | WP_001094436.1 |
| Coordinates | 323461..323838 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7MN76 |
| Locus tag | KHZ70_RS01560 | Protein ID | WP_015953067.1 |
| Coordinates | 323885..324262 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KHZ70_RS01530 (319360) | 319360..319896 | + | 537 | WP_000942807.1 | GspM family type II secretion system protein YghD | - |
| KHZ70_RS01535 (320231) | 320231..321766 | - | 1536 | WP_000492897.1 | EAL domain-containing protein | - |
| KHZ70_RS01540 (321837) | 321837..322682 | - | 846 | WP_001280513.1 | DUF4942 domain-containing protein | - |
| KHZ70_RS01545 (322767) | 322767..322964 | - | 198 | WP_000839254.1 | DUF957 domain-containing protein | - |
| KHZ70_RS01550 (322976) | 322976..323464 | - | 489 | WP_000761714.1 | DUF5983 family protein | - |
| KHZ70_RS01555 (323461) | 323461..323838 | - | 378 | WP_001094436.1 | TA system toxin CbtA family protein | Toxin |
| KHZ70_RS01560 (323885) | 323885..324262 | - | 378 | WP_015953067.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KHZ70_RS01565 (324341) | 324341..324562 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| KHZ70_RS01570 (324631) | 324631..325107 | - | 477 | WP_001186756.1 | RadC family protein | - |
| KHZ70_RS01575 (325122) | 325122..325607 | - | 486 | WP_000860054.1 | antirestriction protein | - |
| KHZ70_RS01580 (325698) | 325698..326516 | - | 819 | WP_001175142.1 | DUF932 domain-containing protein | - |
| KHZ70_RS01585 (326606) | 326606..326839 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| KHZ70_RS01590 (326845) | 326845..327522 | - | 678 | WP_001097312.1 | hypothetical protein | - |
| KHZ70_RS01595 (327670) | 327670..328350 | - | 681 | WP_001282927.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM | 219218..452678 | 233460 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13958.84 Da Isoelectric Point: 6.8603
>T202417 WP_001094436.1 NZ_CP074576:c323838-323461 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
Download Length: 378 bp
>T202417 NZ_CP099387:c2980468-2980136 [Citrobacter braakii]
ATGGACAGAGGAGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTGCTTAT
CGTTTCTCCTGCATCATTTAATAAGTTCACCCGGCTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGTGTGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAACCCAGAACGATT
GATATGGGGGCCCGGAACGGTAAGTGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTAAGCTGA
ATGGACAGAGGAGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTGCTTAT
CGTTTCTCCTGCATCATTTAATAAGTTCACCCGGCTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGTGTGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAACCCAGAACGATT
GATATGGGGGCCCGGAACGGTAAGTGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTAAGCTGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13766.60 Da Isoelectric Point: 6.2021
>AT202417 WP_015953067.1 NZ_CP074576:c324262-323885 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT202417 NZ_CP099387:c2980726-2980469 [Citrobacter braakii]
ATGTATACCACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGCGCT
GTCGACAGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGACCTCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGTGATGAGGATAGGGAATGGATTGATGCGCCTGCAGTG
GGCAAGGAGATCCTGTAA
ATGTATACCACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGCGCT
GTCGACAGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGACCTCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGTGATGAGGATAGGGAATGGATTGATGCGCCTGCAGTG
GGCAAGGAGATCCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2L1N0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z3CIS0 |