Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2531368..2532031 Replicon chromosome
Accession NZ_CP074572
Organism Shewanella dokdonensis strain DSM 23626

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KHX94_RS12160 Protein ID WP_213680842.1
Coordinates 2531368..2531547 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KHX94_RS12165 Protein ID WP_213680843.1
Coordinates 2531600..2532031 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHX94_RS12120 (KHX94_12115) 2526514..2527002 + 489 WP_213680834.1 hypothetical protein -
KHX94_RS12125 (KHX94_12120) 2527081..2527272 + 192 WP_213680835.1 hypothetical protein -
KHX94_RS21165 (KHX94_12125) 2527596..2528294 + 699 WP_280529658.1 replication endonuclease -
KHX94_RS20535 (KHX94_12130) 2528231..2529526 + 1296 Protein_2418 replication endonuclease -
KHX94_RS12140 (KHX94_12135) 2529540..2529764 + 225 WP_213680838.1 hypothetical protein -
KHX94_RS12145 (KHX94_12140) 2529761..2530054 + 294 WP_213680839.1 hypothetical protein -
KHX94_RS12150 (KHX94_12145) 2530051..2530308 + 258 WP_213680840.1 hypothetical protein -
KHX94_RS12155 (KHX94_12150) 2530688..2530978 - 291 WP_213680841.1 helix-turn-helix transcriptional regulator -
KHX94_RS12160 (KHX94_12155) 2531368..2531547 + 180 WP_213680842.1 type II toxin-antitoxin system HicA family toxin Toxin
KHX94_RS12165 (KHX94_12160) 2531600..2532031 + 432 WP_213680843.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KHX94_RS12170 (KHX94_12165) 2532028..2532282 - 255 WP_280529659.1 ogr/Delta-like zinc finger family protein -
KHX94_RS12175 (KHX94_12170) 2532412..2533251 - 840 WP_244859134.1 contractile injection system protein, VgrG/Pvc8 family -
KHX94_RS12180 (KHX94_12175) 2533457..2533900 - 444 WP_213680845.1 phage tail protein -
KHX94_RS12185 (KHX94_12180) 2533906..2536527 - 2622 WP_213680846.1 phage tail tape measure protein -
KHX94_RS12190 (KHX94_12185) 2536520..2536657 - 138 WP_213680847.1 GpE family phage tail protein -
KHX94_RS12195 (KHX94_12190) 2536662..2536958 - 297 WP_213680848.1 phage tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2523086..2556442 33356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6650.74 Da        Isoelectric Point: 10.6223

>T202412 WP_213680842.1 NZ_CP074572:2531368-2531547 [Shewanella dokdonensis]
VKSADLIKLLESNGWQLVSVRGSHHKFRHPDYEDPVVVPHPKKDLGKGLVQKLKRQAGL

Download         Length: 180 bp

>T202412 NZ_CP099386:c4696383-4696009 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15753.86 Da        Isoelectric Point: 4.2470

>AT202412 WP_213680843.1 NZ_CP074572:2531600-2532031 [Shewanella dokdonensis]
MLYPIAIEIGDTDVAYGVAFPDLAGCFSAGDTLEEALSNAKEAAEMYLEDLAERGKLPPQAGDLATWQKDPEYQGWAWAV
VDVDIEPYMGKAAKINVTLPTLVTKRIDDIVKQMPEYKSRSNFLQIAAMRELARSKEHSESAA

Download         Length: 432 bp

>AT202412 NZ_CP099386:c4696625-4696383 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTAAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References