Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2531368..2532031 Replicon chromosome
Accession NZ_CP074572
Organism Shewanella dokdonensis strain DSM 23626

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KHX94_RS12160 Protein ID WP_213680842.1
Coordinates 2531368..2531547 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KHX94_RS12165 Protein ID WP_213680843.1
Coordinates 2531600..2532031 (+) Length 144 a.a.

Genomic Context

KHX94_RS12120KHX94_RS12125KHX94_RS21165KHX94_RS20535KHX94_RS12140KHX94_RS12145KHX94_RS12150KHX94_RS12160KHX94_RS12165KHX94_RS12155KHX94_RS12170KHX94_RS12175KHX94_RS12180KHX94_RS12185KHX94_RS12190KHX94_RS12195
Location: 2526514..2527002 (489 bp)
Type: Others
Protein ID: WP_213680834.1
Location: 2527081..2527272 (192 bp)
Type: Others
Protein ID: WP_213680835.1
Location: 2527596..2528294 (699 bp)
Type: Others
Protein ID: WP_280529658.1
Location: 2528231..2529526 (1296 bp)
Type: Others
Protein ID: Protein_2418
Location: 2529540..2529764 (225 bp)
Type: Others
Protein ID: WP_213680838.1
Location: 2529761..2530054 (294 bp)
Type: Others
Protein ID: WP_213680839.1
Location: 2530051..2530308 (258 bp)
Type: Others
Protein ID: WP_213680840.1
Location: 2531368..2531547 (180 bp)
Type: Toxin
Protein ID: WP_213680842.1
Location: 2531600..2532031 (432 bp)
Type: Antitoxin
Protein ID: WP_213680843.1
Location: 2530688..2530978 (291 bp)
Type: Others
Protein ID: WP_213680841.1
Location: 2532028..2532282 (255 bp)
Type: Others
Protein ID: WP_280529659.1
Location: 2532412..2533251 (840 bp)
Type: Others
Protein ID: WP_244859134.1
Location: 2533457..2533900 (444 bp)
Type: Others
Protein ID: WP_213680845.1
Location: 2533906..2536527 (2622 bp)
Type: Others
Protein ID: WP_213680846.1
Location: 2536520..2536657 (138 bp)
Type: Others
Protein ID: WP_213680847.1
Location: 2536662..2536958 (297 bp)
Type: Others
Protein ID: WP_213680848.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KHX94_RS12120 (KHX94_12115)2526514..2527002+489WP_213680834.1hypothetical protein-
KHX94_RS12125 (KHX94_12120)2527081..2527272+192WP_213680835.1hypothetical protein-
KHX94_RS21165 (KHX94_12125)2527596..2528294+699WP_280529658.1replication endonuclease-
KHX94_RS20535 (KHX94_12130)2528231..2529526+1296Protein_2418replication endonuclease-
KHX94_RS12140 (KHX94_12135)2529540..2529764+225WP_213680838.1hypothetical protein-
KHX94_RS12145 (KHX94_12140)2529761..2530054+294WP_213680839.1hypothetical protein-
KHX94_RS12150 (KHX94_12145)2530051..2530308+258WP_213680840.1hypothetical protein-
KHX94_RS12155 (KHX94_12150)2530688..2530978-291WP_213680841.1helix-turn-helix transcriptional regulator-
KHX94_RS12160 (KHX94_12155)2531368..2531547+180WP_213680842.1type II toxin-antitoxin system HicA family toxinToxin
KHX94_RS12165 (KHX94_12160)2531600..2532031+432WP_213680843.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
KHX94_RS12170 (KHX94_12165)2532028..2532282-255WP_280529659.1ogr/Delta-like zinc finger family protein-
KHX94_RS12175 (KHX94_12170)2532412..2533251-840WP_244859134.1contractile injection system protein, VgrG/Pvc8 family-
KHX94_RS12180 (KHX94_12175)2533457..2533900-444WP_213680845.1phage tail protein-
KHX94_RS12185 (KHX94_12180)2533906..2536527-2622WP_213680846.1phage tail tape measure protein-
KHX94_RS12190 (KHX94_12185)2536520..2536657-138WP_213680847.1GpE family phage tail protein-
KHX94_RS12195 (KHX94_12190)2536662..2536958-297WP_213680848.1phage tail assembly protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2523086..255644233356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6650.74 Da        Isoelectric Point: 10.6223

>T202412 WP_213680842.1 NZ_CP074572:2531368-2531547 [Shewanella dokdonensis]
VKSADLIKLLESNGWQLVSVRGSHHKFRHPDYEDPVVVPHPKKDLGKGLVQKLKRQAGL

Download         Length: 180 bp

>T202412 NZ_CP099386:c4696383-4696009 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15753.86 Da        Isoelectric Point: 4.2470

>AT202412 WP_213680843.1 NZ_CP074572:2531600-2532031 [Shewanella dokdonensis]
MLYPIAIEIGDTDVAYGVAFPDLAGCFSAGDTLEEALSNAKEAAEMYLEDLAERGKLPPQAGDLATWQKDPEYQGWAWAV
VDVDIEPYMGKAAKINVTLPTLVTKRIDDIVKQMPEYKSRSNFLQIAAMRELARSKEHSESAA

Download         Length: 432 bp

>AT202412 NZ_CP099386:c4696625-4696383 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTAAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References