Detailed information of TA system TA202412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2531368..2532031
• Replicon: chromosome
• Accession: NZ_CP074572
• Organism: Shewanella dokdonensis strain DSM 23626

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KHX94_RS12160
• Protein ID: WP_213680842.1
• Coordinates: 2531368..2531547 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KHX94_RS12165
• Protein ID: WP_213680843.1
• Coordinates: 2531600..2532031 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHX94_RS12120 (KHX94_12115)	2526514..2527002	+	489	WP_213680834.1	hypothetical protein	-
KHX94_RS12125 (KHX94_12120)	2527081..2527272	+	192	WP_213680835.1	hypothetical protein	-
KHX94_RS21165 (KHX94_12125)	2527596..2528294	+	699	WP_280529658.1	replication endonuclease	-
KHX94_RS20535 (KHX94_12130)	2528231..2529526	+	1296	Protein_2418	replication endonuclease	-
KHX94_RS12140 (KHX94_12135)	2529540..2529764	+	225	WP_213680838.1	hypothetical protein	-
KHX94_RS12145 (KHX94_12140)	2529761..2530054	+	294	WP_213680839.1	hypothetical protein	-
KHX94_RS12150 (KHX94_12145)	2530051..2530308	+	258	WP_213680840.1	hypothetical protein	-
KHX94_RS12155 (KHX94_12150)	2530688..2530978	-	291	WP_213680841.1	helix-turn-helix transcriptional regulator	-
KHX94_RS12160 (KHX94_12155)	2531368..2531547	+	180	WP_213680842.1	type II toxin-antitoxin system HicA family toxin	Toxin
KHX94_RS12165 (KHX94_12160)	2531600..2532031	+	432	WP_213680843.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KHX94_RS12170 (KHX94_12165)	2532028..2532282	-	255	WP_280529659.1	ogr/Delta-like zinc finger family protein	-
KHX94_RS12175 (KHX94_12170)	2532412..2533251	-	840	WP_244859134.1	contractile injection system protein, VgrG/Pvc8 family	-
KHX94_RS12180 (KHX94_12175)	2533457..2533900	-	444	WP_213680845.1	phage tail protein	-
KHX94_RS12185 (KHX94_12180)	2533906..2536527	-	2622	WP_213680846.1	phage tail tape measure protein	-
KHX94_RS12190 (KHX94_12185)	2536520..2536657	-	138	WP_213680847.1	GpE family phage tail protein	-
KHX94_RS12195 (KHX94_12190)	2536662..2536958	-	297	WP_213680848.1	phage tail assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2523086..2556442	33356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6650.74 Da
• Isoelectric Point: 10.6223

>T202412 WP_213680842.1 NZ_CP074572:2531368-2531547 [Shewanella dokdonensis]
VKSADLIKLLESNGWQLVSVRGSHHKFRHPDYEDPVVVPHPKKDLGKGLVQKLKRQAGL

Nucleotide

• Length: 180 bp

>T202412 NZ_CP099386:c4696383-4696009 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15753.86 Da
• Isoelectric Point: 4.2470

>AT202412 WP_213680843.1 NZ_CP074572:2531600-2532031 [Shewanella dokdonensis]
MLYPIAIEIGDTDVAYGVAFPDLAGCFSAGDTLEEALSNAKEAAEMYLEDLAERGKLPPQAGDLATWQKDPEYQGWAWAV
VDVDIEPYMGKAAKINVTLPTLVTKRIDDIVKQMPEYKSRSNFLQIAAMRELARSKEHSESAA

Nucleotide

• Length: 432 bp

>AT202412 NZ_CP099386:c4696625-4696383 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTAAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA