Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4883236..4884836 Replicon chromosome
Accession NZ_CP074570
Organism Paraneptunicella aestuarii strain NBU2194

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KIH87_RS19230 Protein ID WP_232359468.1
Coordinates 4883236..4884546 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KIH87_RS19235 Protein ID WP_232359469.1
Coordinates 4884546..4884836 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH87_RS19205 (KIH87_19270) 4878279..4878671 + 393 WP_232359463.1 PIN domain nuclease -
KIH87_RS19210 (KIH87_19275) 4878766..4880181 + 1416 WP_232359464.1 aminotransferase class V-fold PLP-dependent enzyme -
KIH87_RS19215 (KIH87_19280) 4880235..4881455 - 1221 WP_232359465.1 type II toxin-antitoxin system HipA family toxin -
KIH87_RS19220 (KIH87_19285) 4881445..4881738 - 294 WP_232359466.1 helix-turn-helix transcriptional regulator -
KIH87_RS19225 (KIH87_19290) 4882091..4883176 + 1086 WP_232359467.1 hypothetical protein -
KIH87_RS19230 (KIH87_19295) 4883236..4884546 - 1311 WP_232359468.1 type II toxin-antitoxin system HipA family toxin Toxin
KIH87_RS19235 (KIH87_19300) 4884546..4884836 - 291 WP_232359469.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KIH87_RS19240 (KIH87_19305) 4885314..4885523 - 210 WP_232359470.1 hypothetical protein -
KIH87_RS19245 (KIH87_19310) 4885505..4888624 - 3120 WP_232359471.1 PKD domain-containing protein -
KIH87_RS19250 (KIH87_19315) 4888906..4889322 - 417 WP_232359472.1 F0F1 ATP synthase subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49050.47 Da        Isoelectric Point: 8.4086

>T202408 WP_232359468.1 NZ_CP074570:c4884546-4883236 [Paraneptunicella aestuarii]
MKKLLAYMNNEYVGELIKLSNGAHQFTYSEQWLLSPRSRPVSLSLPLRKNTYTSDKVINYFDNLLPDSPLIRQRVVARYE
AESAQPFDLLEKIGRDSVGALTLLPEGTSFQNNTLNYEELNDAHLARILSAYKAQAPLGMLKEDQDFRISIAGAQEKTAL
LKVNGKWCLPKGNTATTHIIKLPIGEIKQPDATLDMSDSVENEYFCIKLAGALGFSVPNVEIVRVGNIKALAVERFDRRW
NKNKDWILRLPQEDICQVQGKPSAIKYESEGGAGITDVMDILMGSKNALQDRETFMRFQVFQWIVGATDGHAKNFSLFIE
AGGAYRLTPFYDILSAFPVVGGVGLNIRDLKLAMGLKASKGKKYRIDDIFPRHFLATAKQVGFSQERMQEIMDELADCFE
VQAKKVLSELPDNFPIAIADNIVEHSLKQVKRLQRK

Download         Length: 1311 bp

>T202408 NZ_CP099386:c2782466-2782363 [Citrobacter braakii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11006.65 Da        Isoelectric Point: 5.5802

>AT202408 WP_232359469.1 NZ_CP074570:c4884836-4884546 [Paraneptunicella aestuarii]
MHMLIFLDGVYSPVQLANKLKLYREQKGWTQTDIAKRIGVKQSTISNFENHPDKTQLATLFKIIQAMEVVLQVHLPFPPG
DELKAANDVIDDEDNW

Download         Length: 291 bp

>AT202408 NZ_CP099386:2782358-2782501 [Citrobacter braakii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References