Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1292748..1293302 Replicon chromosome
Accession NZ_CP074570
Organism Paraneptunicella aestuarii strain NBU2194

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KIH87_RS05435 Protein ID WP_232360523.1
Coordinates 1293012..1293302 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KIH87_RS05430 Protein ID WP_232360522.1
Coordinates 1292748..1293011 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH87_RS05400 (KIH87_05425) 1288081..1289295 + 1215 WP_232360518.1 DUF4062 domain-containing protein -
KIH87_RS05405 (KIH87_05430) 1289519..1290328 - 810 WP_232360519.1 M48 family metallopeptidase -
KIH87_RS05410 (KIH87_05435) 1290476..1290877 - 402 WP_232360520.1 OsmC family protein -
KIH87_RS05415 (KIH87_05440) 1291314..1292093 + 780 WP_232360521.1 hypothetical protein -
KIH87_RS05430 (KIH87_05455) 1292748..1293011 + 264 WP_232360522.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KIH87_RS05435 (KIH87_05460) 1293012..1293302 + 291 WP_232360523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIH87_RS05440 (KIH87_05465) 1293967..1294596 + 630 WP_232360524.1 hypothetical protein -
KIH87_RS05445 (KIH87_05470) 1294698..1295402 + 705 WP_232360525.1 competence protein CoiA family protein -
KIH87_RS05450 (KIH87_05475) 1295948..1296247 - 300 WP_232360526.1 type II toxin-antitoxin system RelE/ParE family toxin -
KIH87_RS05455 (KIH87_05480) 1296231..1296491 - 261 WP_232360527.1 type II toxin-antitoxin system ParD family antitoxin -
KIH87_RS05460 (KIH87_05485) 1296711..1298069 - 1359 WP_232360528.1 saccharopine dehydrogenase NADP-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-90)

Antitoxin

Antitoxin ParD

(4-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11125.02 Da        Isoelectric Point: 9.7714

>T202403 WP_232360523.1 NZ_CP074570:1293012-1293302 [Paraneptunicella aestuarii]
MLLIHIQVKAKDDLKKILIHSIEQWGLERAEQYYDELGAGITSIAENPQLGFARDDLKTGYRQLTVAKHCVFYRVSKSKI
HVIRILHERMLKSGHL

Download         Length: 291 bp

>T202403 NZ_CP099385:c4835655-4835281 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGTGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9696.91 Da        Isoelectric Point: 4.7360

>AT202403 WP_232360522.1 NZ_CP074570:1292748-1293011 [Paraneptunicella aestuarii]
MSQAKTQTLSLGEHWNAFIAAQIEDGRYASASEVVRDALRLMEEKRSASKLEQLRAALREGEESGDAGVFDLEAIKREAL
KEMELSK

Download         Length: 264 bp

>AT202403 NZ_CP099385:c4835897-4835655 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References