Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 965348..965940 Replicon chromosome
Accession NZ_CP074570
Organism Paraneptunicella aestuarii strain NBU2194

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag KIH87_RS03985 Protein ID WP_232360244.1
Coordinates 965599..965940 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag KIH87_RS03980 Protein ID WP_232360243.1
Coordinates 965348..965599 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH87_RS03965 (KIH87_03985) 960382..961320 + 939 WP_232360240.1 MoxR family ATPase -
KIH87_RS03970 (KIH87_03990) 961329..964109 + 2781 WP_232360241.1 formylglycine-generating enzyme family protein -
KIH87_RS03975 (KIH87_03995) 964113..965036 + 924 WP_232360242.1 formylglycine-generating enzyme family protein -
KIH87_RS03980 (KIH87_04000) 965348..965599 + 252 WP_232360243.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KIH87_RS03985 (KIH87_04005) 965599..965940 + 342 WP_232360244.1 type II toxin-antitoxin system ChpB family toxin Toxin
KIH87_RS03990 (KIH87_04010) 966042..967112 + 1071 WP_232360245.1 zinc-binding dehydrogenase -
KIH87_RS03995 (KIH87_04015) 967235..968302 + 1068 WP_232360246.1 Gfo/Idh/MocA family oxidoreductase -
KIH87_RS04000 (KIH87_04020) 968295..969530 + 1236 WP_232360247.1 methyltransferase domain-containing protein -
KIH87_RS04005 (KIH87_04025) 969527..970054 + 528 WP_232360248.1 WbuC family cupin fold metalloprotein -
KIH87_RS04010 (KIH87_04030) 970044..970781 + 738 WP_232360249.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12143.30 Da        Isoelectric Point: 8.5392

>T202402 WP_232360244.1 NZ_CP074570:965599-965940 [Paraneptunicella aestuarii]
MAVFERGDIVRVCLNPTSGKEVQGDFRPCLVLSPKSFNKLGITLIAPITQGGDFSRFKGFTVALMGAGTETQGVILVNAI
RMVDLQARKAKKLEQTPANIVEEVLAILGAILE

Download         Length: 342 bp

>T202402 NZ_CP099385:4361971-4362258 [Citrobacter braakii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8936.41 Da        Isoelectric Point: 4.7718

>AT202402 WP_232360243.1 NZ_CP074570:965348-965599 [Paraneptunicella aestuarii]
MEIVLRKIGNSKGAVIPAALLKELGLNVGDTLEAVAKDGNLIMAPKNKKKYTLAELLAKCDANAPMPDEFKEWDNLDAVG
NEV

Download         Length: 252 bp

>AT202402 NZ_CP099385:4361732-4361971 [Citrobacter braakii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References