Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 735482..736008 Replicon chromosome
Accession NZ_CP074570
Organism Paraneptunicella aestuarii strain NBU2194

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag KIH87_RS03125 Protein ID WP_232360081.1
Coordinates 735745..736008 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KIH87_RS03120 Protein ID WP_232360080.1
Coordinates 735482..735745 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH87_RS03100 (KIH87_03120) 731088..732287 + 1200 WP_232360076.1 tyrosine--tRNA ligase -
KIH87_RS03105 (KIH87_03125) 732390..733724 - 1335 WP_232360077.1 FAD-binding oxidoreductase -
KIH87_RS03110 (KIH87_03130) 733724..734302 - 579 WP_232360078.1 GNAT family N-acetyltransferase -
KIH87_RS03115 (KIH87_03135) 734548..735354 + 807 WP_232360079.1 thioesterase family protein -
KIH87_RS03120 (KIH87_03140) 735482..735745 + 264 WP_232360080.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KIH87_RS03125 (KIH87_03145) 735745..736008 + 264 WP_232360081.1 Txe/YoeB family addiction module toxin Toxin
KIH87_RS03130 (KIH87_03150) 736107..737480 - 1374 WP_232361419.1 adenosylhomocysteinase -
KIH87_RS03135 (KIH87_03155) 737793..738743 - 951 WP_232360082.1 cobalamin biosynthesis protein -
KIH87_RS03140 (KIH87_03160) 738762..739460 - 699 WP_232360083.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
KIH87_RS03145 (KIH87_03165) 739476..740645 - 1170 WP_232360084.1 carboxynorspermidine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10285.69 Da        Isoelectric Point: 8.8578

>T202401 WP_232360081.1 NZ_CP074570:735745-736008 [Paraneptunicella aestuarii]
MTSRVLSWTDESWSDYLYWQTQDKKTLKRINKLILDVKRSPFDGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDGAITV
ISCRYHY

Download         Length: 264 bp

>T202401 NZ_CP099385:c4350075-4349734 [Citrobacter braakii]
ATGAAATTTCTACTTGCAACAAACTTGCGGTCGGCGAAACCATGCCTGTCATCCGTTGCTGTCTGGCAAATGCTGCTTGA
ACGCCTGCTGGAAAAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCATGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATCTTCTGGTGGAAAAGTACGAACTGGTTCGTATTGATCGTAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9728.82 Da        Isoelectric Point: 4.7914

>AT202401 WP_232360080.1 NZ_CP074570:735482-735745 [Paraneptunicella aestuarii]
MRIVSFTEARNSLKAVLDNVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNKSIAQYKEGKTTQRG
LEDENGA

Download         Length: 264 bp

>AT202401 NZ_CP099385:c4350452-4350096 [Citrobacter braakii]
ATGAACAATCACTCCGAATCCGGTACAACGCCGGAGAATACCTCCTGCCCGCAGTGGGGGCTCAAACGTGCTATTACACC
TTGTTTTGGTGCCCGCCTGGTACAGGAGGGAAACCGACTGCATTTTCTCCCTGACCGGGCCGGATTTAACTGTGCTTTCA
GCGACGATGACTCGCTGCGCCTGGATCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGCTGATGCTCACCAGCAGAGAA
CTATCTCCCCGGTATCAGCACTGCGTCACGCTATATCACAACGGGCTCACTTGCGAAGCCGACACACTTGGCAGTTGCGG
TTACGTATACATCGCCGTTTATCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References