Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5066241..5067922 Replicon chromosome
Accession NZ_CP074558
Organism Klebsiella pneumoniae strain S39_CRE40

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag KHW03_RS25150 Protein ID WP_002885155.1
Coordinates 5066241..5067158 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag KHW03_RS25155 Protein ID WP_004151732.1
Coordinates 5067164..5067922 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW03_RS25130 (KHW03_25050) 5061547..5063067 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
KHW03_RS25135 (KHW03_25055) 5063064..5064062 + 999 WP_002885172.1 ribose ABC transporter permease -
KHW03_RS25140 (KHW03_25060) 5064093..5065034 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
KHW03_RS25145 (KHW03_25065) 5065109..5066116 + 1008 WP_004151731.1 carbohydrate kinase family protein -
KHW03_RS25150 (KHW03_25070) 5066241..5067158 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KHW03_RS25155 (KHW03_25075) 5067164..5067922 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
KHW03_RS25160 (KHW03_25080) 5068008..5068736 - 729 WP_002885152.1 response regulator transcription factor -
KHW03_RS25165 (KHW03_25085) 5069009..5071156 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
KHW03_RS25170 (KHW03_25090) 5071386..5072072 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T202396 WP_002885155.1 NZ_CP074558:c5067158-5066241 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T202396 NZ_CP099385:846174-846581 [Citrobacter braakii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAATGGCTTTCGCTGCTCATTCATGGGCTGGTGGCGGT
ATTTATATTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTCTGCTCTCTCTGGTGGTGTTCGATAGCG
TCCGTAGCCAGCGCCGAATCAATGCCTGTCAGGGCGAGATTCGGCTGTTGATGGACGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGACTATTGCTAGCGCACCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTACGTTCCGATGCCGGAAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGACGCGGAGTGGCGGGATTTGCGGCGGTTAATACTGCAACAGGCGAAGC
AGGGATAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT202396 WP_004151732.1 NZ_CP074558:c5067922-5067164 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT202396 NZ_CP099385:845927-846193 [Citrobacter braakii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGATGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGCTCAGCTAGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References