202395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4907409..4907925 Replicon chromosome
Accession NZ_CP074558
Organism Klebsiella pneumoniae strain S39_CRE40

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHW03_RS24335 Protein ID WP_002886902.1
Coordinates 4907409..4907693 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHW03_RS24340 Protein ID WP_002886901.1
Coordinates 4907683..4907925 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW03_RS24310 (KHW03_24230) 4902893..4903156 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KHW03_RS24315 (KHW03_24235) 4903286..4903459 + 174 WP_002886906.1 hypothetical protein -
KHW03_RS24320 (KHW03_24240) 4903462..4904205 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHW03_RS24325 (KHW03_24245) 4904562..4906700 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KHW03_RS24330 (KHW03_24250) 4906941..4907405 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHW03_RS24335 (KHW03_24255) 4907409..4907693 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHW03_RS24340 (KHW03_24260) 4907683..4907925 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHW03_RS24345 (KHW03_24265) 4908003..4909913 - 1911 WP_270104185.1 PRD domain-containing protein -
KHW03_RS24350 (KHW03_24270) 4909936..4911090 - 1155 WP_002886900.1 lactonase family protein -
KHW03_RS24355 (KHW03_24275) 4911156..4911896 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202395 WP_002886902.1 NZ_CP074558:c4907693-4907409 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202395 NZ_CP099385:43316-43657 [Citrobacter braakii]
ATGTGGGAAGTGGAAACAACGGATGTTTTCGATAAATGGTTTGACGTACAGACCGAGGCGCTCAAGGAAGATATGCTCGC
AGCGATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGCAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTGCAGCATCAGGGCAACCCGATTCGGGCGTTCTTCGTGTTTGATCCTTCTCGCCATGGCATC
GTGTTATGCGCTGGCGATAAAACAGGGTTAAACGAGAAGAAATTCTATAAAGAGATGATCAGGCTTGCTGACGCTGAGTA
CCGAAATCACCTTAATAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202395 WP_002886901.1 NZ_CP074558:c4907925-4907683 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202395 NZ_CP099385:43666-43965 [Citrobacter braakii]
ATGGCGACGCTTAAAGAATTGATGGCGAAACAAAGCCCGGAAAGCCAGGAGCGCATTGCTGAAAAAGTAGAAGTGCTACG
TCAGGTGATTGCGTTAAATATGTTACGGGAAGAACTGAATCTCTCTCAGGCGGAACTTGCCTCGGCAATGGGCGTTAAGC
AGCCAACAATCGCAAAAATGGAACAGGCGGATAACGATCCTCGTCTGTCGACGCTTAAGCGTTATGTCACGGCGTTAGGT
GGCGAACTGAGCATTGATGTTAAGTTACCGACAGGTAAAAGAGTCGCGTTTCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References