Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870686..871343 Replicon chromosome
Accession NZ_CP074558
Organism Klebsiella pneumoniae strain S39_CRE40

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KHW03_RS04395 Protein ID WP_002916310.1
Coordinates 870933..871343 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KHW03_RS04390 Protein ID WP_002916312.1
Coordinates 870686..870952 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW03_RS04365 (KHW03_04360) 865842..867275 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KHW03_RS04370 (KHW03_04365) 867394..868122 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KHW03_RS04375 (KHW03_04370) 868172..868483 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KHW03_RS04380 (KHW03_04375) 868647..869306 + 660 WP_002916317.1 hemolysin III family protein -
KHW03_RS04385 (KHW03_04380) 869457..870440 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KHW03_RS04390 (KHW03_04385) 870686..870952 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KHW03_RS04395 (KHW03_04390) 870933..871343 + 411 WP_002916310.1 protein YgfX Toxin
KHW03_RS04400 (KHW03_04395) 871350..871871 - 522 WP_002916308.1 flavodoxin FldB -
KHW03_RS04405 (KHW03_04400) 871972..872868 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KHW03_RS04410 (KHW03_04405) 872891..873604 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHW03_RS04415 (KHW03_04410) 873610..875343 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T202383 WP_002916310.1 NZ_CP074558:870933-871343 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T202383 NZ_CP099382:c4536272-4535991 [Citrobacter braakii]
ATGACCTATAACCTGGAGTTTTTAGATATTGCGCTCAAGGAGTGGCGCAAGCTTTCCCCTGCATTACGCGAGCAGTTCAA
AAAGAAACTGGCGGAGCGGCTGGAAAATCCCCATGTCCCTGCCGCCCGCCTTTCCGGCAAATTACACCGTTACAAAATCA
AGCTTCGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTGGGCAGA
CGTGATGGTGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT202383 WP_002916312.1 NZ_CP074558:870686-870952 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202383 NZ_CP099382:c4536510-4536262 [Citrobacter braakii]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGTATCACCGACCTGAAACGTAACCCAATGGGGACAGTCAACGCCGG
GGAGGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTTTATGCGTATCTGC
TGGAGCTGGTAGAAGACGCCGAGCTGAACCGTATCGCCGACGAACGTGAAGATGGAAAGCGAATAAAGGTGTCTTTAAAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References