Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4880972..4881488 Replicon chromosome
Accession NZ_CP074553
Organism Klebsiella pneumoniae strain S37_CRE38

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHW02_RS24110 Protein ID WP_002886902.1
Coordinates 4880972..4881256 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHW02_RS24115 Protein ID WP_002886901.1
Coordinates 4881246..4881488 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW02_RS24085 (KHW02_24010) 4876456..4876719 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KHW02_RS24090 (KHW02_24015) 4876849..4877022 + 174 WP_002886906.1 hypothetical protein -
KHW02_RS24095 (KHW02_24020) 4877025..4877768 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHW02_RS24100 (KHW02_24025) 4878125..4880263 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KHW02_RS24105 (KHW02_24030) 4880504..4880968 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHW02_RS24110 (KHW02_24035) 4880972..4881256 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHW02_RS24115 (KHW02_24040) 4881246..4881488 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHW02_RS24120 (KHW02_24045) 4881566..4883476 - 1911 WP_004152270.1 PRD domain-containing protein -
KHW02_RS24125 (KHW02_24050) 4883499..4884653 - 1155 WP_002886900.1 lactonase family protein -
KHW02_RS24130 (KHW02_24055) 4884719..4885459 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202375 WP_002886902.1 NZ_CP074553:c4881256-4880972 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202375 NZ_CP099381:c4859075-4858701 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGAAATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202375 WP_002886901.1 NZ_CP074553:c4881488-4881246 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202375 NZ_CP099381:c4859317-4859075 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References