Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4788964..4790602 Replicon chromosome
Accession NZ_CP074545
Organism Klebsiella aerogenes strain S33_CRE34

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U9APU8
Locus tag KHW00_RS23205 Protein ID WP_001314390.1
Coordinates 4788964..4790292 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A754E9C8
Locus tag KHW00_RS23210 Protein ID WP_001314389.1
Coordinates 4790297..4790602 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW00_RS23185 (KHW00_23110) 4784941..4786425 + 1485 WP_001060567.1 chromosome partitioning protein ParB -
KHW00_RS23190 (KHW00_23115) 4786409..4786948 + 540 WP_000938043.1 DUF2857 domain-containing protein -
KHW00_RS23195 (KHW00_23120) 4786967..4788100 + 1134 WP_015368501.1 STY4528 family pathogenicity island replication protein -
KHW00_RS23200 (KHW00_23125) 4788166..4788837 - 672 WP_000863683.1 hypothetical protein -
KHW00_RS23205 (KHW00_23130) 4788964..4790292 - 1329 WP_001314390.1 type II toxin-antitoxin system HipA family toxin Toxin
KHW00_RS23210 (KHW00_23135) 4790297..4790602 - 306 WP_001314389.1 helix-turn-helix transcriptional regulator Antitoxin
KHW00_RS23215 (KHW00_23140) 4791153..4793465 + 2313 WP_015368502.1 autotransporter outer membrane beta-barrel domain-containing protein -
KHW00_RS23220 (KHW00_23145) 4793572..4794165 + 594 WP_015368503.1 hypothetical protein -
KHW00_RS23225 (KHW00_23150) 4794523..4795560 - 1038 WP_001230900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50662.34 Da        Isoelectric Point: 4.9669

>T202359 WP_001314390.1 NZ_CP074545:c4790292-4788964 [Klebsiella aerogenes]
MRRTQQRLAIWMNGIRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQSESLEPFDLLAELGRDCVGAIQLLDVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELTGLGRRQVESMMDDI
ISSTPEVIERVSMLLPESFPPELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T202359 NZ_CP099378:c4233325-4233044 [Citrobacter braakii]
ATGACCTATAACCTGGAGTTTTTAGATGTTGCGCTCAAGGAGTGGCGCAAGCTTTCACCCACATTACGCGAGCAGTTCAA
AAAGAAACTGGCGGAGCGGCTGGAAAATCCCCATGTCCCTGCCGCCCGCCTTTCCGGCAAATTACACCGTTACAAAATCA
AGCTTCGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTGGGCAGA
CGTGATGGTGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11363.02 Da        Isoelectric Point: 10.1481

>AT202359 WP_001314389.1 NZ_CP074545:c4790602-4790297 [Klebsiella aerogenes]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMDESEQQKDSPARREKW

Download         Length: 306 bp

>AT202359 NZ_CP099378:c4233563-4233315 [Citrobacter braakii]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGTATCACCGACCTGAAACGTAACCCAATGGGGACAGTCAACGCCGG
GGAAGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCTGCGTTTTACTGCGTGCCGCCTGCGGTCTATGCATATTTGC
TGGAGCTGGCTGAGGATGCCGAGCTGAACCGCATCGCCGACGAGCGAGAAGGTGGAAAGCGAATAAAGGTATCTTTAAAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9APU8

Antitoxin

Source ID Structure
AlphaFold DB A0A754E9C8

References