Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2789721..2790460 Replicon chromosome
Accession NZ_CP074545
Organism Klebsiella aerogenes strain S33_CRE34

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag KHW00_RS13560 Protein ID WP_032705770.1
Coordinates 2789975..2790460 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag KHW00_RS13555 Protein ID WP_015366659.1
Coordinates 2789721..2789987 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW00_RS13530 (KHW00_13505) 2785029..2785898 + 870 WP_015366654.1 5'/3'-nucleotidase SurE -
KHW00_RS13535 (KHW00_13510) 2786074..2786631 + 558 WP_224404347.1 LuxR C-terminal-related transcriptional regulator -
KHW00_RS13540 (KHW00_13515) 2786727..2787224 + 498 WP_015366656.1 heme-binding protein -
KHW00_RS13545 (KHW00_13520) 2787628..2788158 + 531 WP_015366657.1 N-acetyltransferase -
KHW00_RS13550 (KHW00_13525) 2788213..2789448 - 1236 WP_015366658.1 MFS transporter -
KHW00_RS13555 (KHW00_13530) 2789721..2789987 + 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
KHW00_RS13560 (KHW00_13535) 2789975..2790460 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
KHW00_RS13565 (KHW00_13540) 2790532..2792148 + 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
KHW00_RS13570 (KHW00_13545) 2792267..2793367 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
KHW00_RS13575 (KHW00_13550) 2793424..2793582 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
KHW00_RS13580 (KHW00_13555) 2793843..2794913 + 1071 WP_015366664.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T202357 WP_032705770.1 NZ_CP074545:2789975-2790460 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T202357 NZ_CP099378:c4115706-4115419 [Citrobacter braakii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCTGAGGAAACATGGTGTTCGCTTTGAGGACGCAAT
ATTGGTTTTCGACGATCCCCAACATCTGTCGCGGCAGGAGCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATTGGTC
TCGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGC
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT202357 WP_015366659.1 NZ_CP074545:2789721-2789987 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT202357 NZ_CP099378:c4115432-4115130 [Citrobacter braakii]
ATGAGCATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATCGATTACAGCGACATTCCCGTGACCGAAGATAAGCAGTGGTCAGAGGCCATTCGCGGTAAGT
TTTTTCGTCCGTTAAAAACGCAGGCGTCGGTGCGCATTGATGCCGATGTGATGGAATGGCTGAAGCGCCCCGGGAAGGGT
TACCAGACGCGTCTCAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References