Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1178261..1178987 Replicon chromosome
Accession NZ_CP074545
Organism Klebsiella aerogenes strain S33_CRE34

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KHW00_RS05735 Protein ID WP_015370123.1
Coordinates 1178261..1178590 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KHW00_RS05740 Protein ID WP_015370124.1
Coordinates 1178643..1178987 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW00_RS05700 (KHW00_05675) 1173629..1173748 - 120 WP_226911500.1 hypothetical protein -
KHW00_RS05705 (KHW00_05680) 1174072..1174299 + 228 WP_071647620.1 DUF1272 domain-containing protein -
KHW00_RS05710 (KHW00_05685) 1174627..1175445 + 819 WP_032706441.1 AraC family transcriptional regulator -
KHW00_RS05715 (KHW00_05690) 1175521..1175883 + 363 WP_015370120.1 cupin domain-containing protein -
KHW00_RS05720 (KHW00_05695) 1176083..1176619 + 537 WP_015370121.1 dihydrofolate reductase family protein -
KHW00_RS05725 (KHW00_05700) 1176795..1177595 + 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
KHW00_RS05730 (KHW00_05705) 1177754..1177855 - 102 Protein_1124 preprotein translocase -
KHW00_RS05735 (KHW00_05710) 1178261..1178590 - 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
KHW00_RS05740 (KHW00_05715) 1178643..1178987 - 345 WP_015370124.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KHW00_RS05745 (KHW00_05720) 1179010..1179231 - 222 WP_015370125.1 DUF987 domain-containing protein -
KHW00_RS05750 (KHW00_05725) 1179252..1179731 - 480 WP_015370126.1 DNA repair protein RadC -
KHW00_RS05755 (KHW00_05730) 1179743..1180222 - 480 WP_032710462.1 antirestriction protein -
KHW00_RS05760 (KHW00_05735) 1180239..1180493 - 255 WP_071647618.1 hypothetical protein -
KHW00_RS05765 (KHW00_05740) 1180493..1181311 - 819 WP_015370128.1 DUF932 domain-containing protein -
KHW00_RS05770 (KHW00_05745) 1181409..1181642 - 234 WP_015370129.1 DUF905 domain-containing protein -
KHW00_RS05775 (KHW00_05750) 1181736..1182572 - 837 WP_015370130.1 hypothetical protein -
KHW00_RS05780 (KHW00_05755) 1182630..1182875 - 246 WP_032710460.1 hypothetical protein -
KHW00_RS05785 (KHW00_05760) 1182875..1183102 - 228 WP_015370132.1 hypothetical protein -
KHW00_RS05790 (KHW00_05765) 1183175..1183582 - 408 WP_032710459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1175521..1205196 29675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(15-113)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T202340 WP_015370123.1 NZ_CP074545:c1178590-1178261 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T202340 NZ_CP099376:c4071423-4071016 [Citrobacter braakii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAATGGCTTTCGTTGCTCATTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTCTGCTCTCTCTGGTGGTGTTCGATAGCG
TCCGTAGCCAGCGCCGAATCAATGCCTGTCAGGGCGAGATTCGGCTGTTGATGGACGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGACTATTGCTAGCGCACCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTACGTTCCGATGCCGGAAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGACGCGGAGTGGCGGGATTTGCGGCGGTTAATACTGCAACAGGCGAAGC
AGGGATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12830.53 Da        Isoelectric Point: 5.8747

>AT202340 WP_015370124.1 NZ_CP074545:c1178987-1178643 [Klebsiella aerogenes]
MSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQAFPVLLKQLELMLVSGELT
SRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 345 bp

>AT202340 NZ_CP099376:c4071670-4071404 [Citrobacter braakii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGATGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGCTCAGCTAGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References