Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 840982..841639 Replicon chromosome
Accession NZ_CP074545
Organism Klebsiella aerogenes strain S33_CRE34

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag KHW00_RS04085 Protein ID WP_015369792.1
Coordinates 841229..841639 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag KHW00_RS04080 Protein ID WP_015369791.1
Coordinates 840982..841248 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW00_RS04055 (KHW00_04050) 836209..837642 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
KHW00_RS04060 (KHW00_04055) 837762..838490 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
KHW00_RS04065 (KHW00_04060) 838541..838852 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
KHW00_RS04070 (KHW00_04065) 839017..839676 + 660 WP_008806429.1 hemolysin III family protein -
KHW00_RS04075 (KHW00_04070) 839775..840758 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
KHW00_RS04080 (KHW00_04075) 840982..841248 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
KHW00_RS04085 (KHW00_04080) 841229..841639 + 411 WP_015369792.1 protein YgfX Toxin
KHW00_RS04090 (KHW00_04085) 841647..842168 - 522 WP_015369793.1 flavodoxin FldB -
KHW00_RS04095 (KHW00_04090) 842269..843165 + 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
KHW00_RS04100 (KHW00_04095) 843188..843901 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KHW00_RS04105 (KHW00_04100) 843907..845640 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T202339 WP_015369792.1 NZ_CP074545:841229-841639 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T202339 NZ_CP099376:c2534562-2534374 [Citrobacter braakii]
GTGAAGCAAAGTGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTGGCTATTACAAACGGCTCAAATCATCTGAAGTTGAG
GTATCAGGGAAGGCGTAGCGTTATGCCCAGGCATCGTGGTGATGAAATAAAAGAAGCCTTGCGAAAATCGATCCTGAAGC
AGCTTGGTTTACAGTCATCATCAATATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT202339 WP_015369791.1 NZ_CP074545:840982-841248 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT202339 NZ_CP099376:c2534342-2533926 [Citrobacter braakii]
ATGCGTTATCCCGTTAATCTAATCCCCGCCGTGGAAGGTGGATTCGTGGTTTCTTTCCCGGATATTCCTGAAGCATTAAC
CCAGGGCGAAACCCGTCATGGGGCTTTGCAGGCTGCGCAGTCTGCATTGGTGACCGCTTTTGAATTCTATTTCGACGATA
ACGAACCGATTCCTTTACCTTCGGCGGTTGGCGCTGAAGGTGACTATGTGGAAATCCCCCTGAGCATTGCGTCGAAGGTT
CTTTTGTTAAATGCCTTTCTTGAATCAAAAATCACCCAGCAGGAGCTGGCAAACAGGATCGGCAGGCCTAAGCAGGAAAT
TACCCGTTTGTTCGATTTAAAACACGCGACAAAAATTGATGCTGTGCAAATAGCTGCACGCGCCTTAGGCAAGGAGCTGT
CAGTAACAATGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References