Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 43201..43844 | Replicon | plasmid pCRE24_2 |
| Accession | NZ_CP074543 | ||
| Organism | Klebsiella pneumoniae strain S24_CRE24 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | D8L2J9 |
| Locus tag | KHV99_RS28670 | Protein ID | WP_001044770.1 |
| Coordinates | 43428..43844 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | KHV99_RS28665 | Protein ID | WP_001261282.1 |
| Coordinates | 43201..43431 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KHV99_RS28630 (KHV99_28530) | 38918..39673 | - | 756 | WP_012539983.1 | replication initiation protein RepE | - |
| KHV99_RS28635 (KHV99_28535) | 40304..40417 | + | 114 | WP_032072094.1 | hypothetical protein | - |
| KHV99_RS28640 (KHV99_28540) | 40546..40803 | + | 258 | WP_032408936.1 | hypothetical protein | - |
| KHV99_RS28645 (KHV99_28545) | 40861..41646 | - | 786 | WP_022644886.1 | site-specific integrase | - |
| KHV99_RS28650 (KHV99_28550) | 41649..42287 | - | 639 | WP_022644887.1 | hypothetical protein | - |
| KHV99_RS28655 (KHV99_28555) | 42336..42656 | - | 321 | WP_032072060.1 | hypothetical protein | - |
| KHV99_RS28660 (KHV99_28560) | 42784..43244 | - | 461 | Protein_50 | hypothetical protein | - |
| KHV99_RS28665 (KHV99_28565) | 43201..43431 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KHV99_RS28670 (KHV99_28570) | 43428..43844 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KHV99_RS28675 (KHV99_28575) | 43918..44136 | + | 219 | Protein_53 | AAA family ATPase | - |
| KHV99_RS28680 (KHV99_28580) | 44201..44905 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| KHV99_RS28685 | 44939..45295 | - | 357 | WP_004199403.1 | hypothetical protein | - |
| KHV99_RS28690 (KHV99_28585) | 45298..45537 | - | 240 | WP_001549892.1 | hypothetical protein | - |
| KHV99_RS28695 (KHV99_28590) | 45624..46286 | - | 663 | WP_001549893.1 | recombinase family protein | - |
| KHV99_RS28700 (KHV99_28595) | 46667..47329 | + | 663 | WP_000516402.1 | division plane positioning ATPase MipZ | - |
| KHV99_RS28705 (KHV99_28600) | 47429..47713 | + | 285 | WP_001185481.1 | hypothetical protein | - |
| KHV99_RS28710 (KHV99_28605) | 47919..48230 | + | 312 | WP_000469598.1 | hypothetical protein | - |
| KHV99_RS28715 (KHV99_28610) | 48266..48550 | + | 285 | WP_001043731.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaKPC-3 / blaSHV-12 / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib | - | 1..115320 | 115320 | |
| - | flank | IS/Tn | - | - | 44201..44905 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T202337 WP_001044770.1 NZ_CP074543:43428-43844 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
>T202337 NZ_CP099376:c1944639-1944286 [Citrobacter braakii]
GTGTGGACGATTAAAACAACGGATATGTTTGATCACTGGTTTTCCTCGCTCAATGATATCGATCGGGCCAGCGTACTTGC
AGCGCTGTTGGTCCTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGCTTAGAGGCTCCCGCTTTAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGACCCGATACGGGCATTTTTCGCTTTTGATCCAGCCCGTACCGGCATT
GTACTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGATCCCGGTTGCAGATCGGGAATTCAC
GAACTGGCTGAACACAATAAAAGAGAAGGAGTAA
GTGTGGACGATTAAAACAACGGATATGTTTGATCACTGGTTTTCCTCGCTCAATGATATCGATCGGGCCAGCGTACTTGC
AGCGCTGTTGGTCCTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGCTTAGAGGCTCCCGCTTTAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGACCCGATACGGGCATTTTTCGCTTTTGATCCAGCCCGTACCGGCATT
GTACTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGATCCCGGTTGCAGATCGGGAATTCAC
GAACTGGCTGAACACAATAAAAGAGAAGGAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT202337 WP_001261282.1 NZ_CP074543:43201-43431 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT202337 NZ_CP099376:c1944281-1943979 [Citrobacter braakii]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGCGAGAAAGTGCAGAAAACGCAGGTCGAAATGGCGAAGGCGCTGGGGATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCGGGGCGCGACCTGAAGCTTTCCACGCTGAAACGCTACGTTGAAGCGACC
GGCGGCAAGCTACGCCTTGATGTTGAACTGCCGGATGGCTCTCACTACGGATTTGTACTATAA
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGCGAGAAAGTGCAGAAAACGCAGGTCGAAATGGCGAAGGCGCTGGGGATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCGGGGCGCGACCTGAAGCTTTCCACGCTGAAACGCTACGTTGAAGCGACC
GGCGGCAAGCTACGCCTTGATGTTGAACTGCCGGATGGCTCTCACTACGGATTTGTACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GYM2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZG3 |