Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5103181..5104862 | Replicon | chromosome |
| Accession | NZ_CP074541 | ||
| Organism | Klebsiella pneumoniae strain S24_CRE24 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | KHV99_RS25365 | Protein ID | WP_002885155.1 |
| Coordinates | 5103181..5104098 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | KHV99_RS25370 | Protein ID | WP_004151732.1 |
| Coordinates | 5104104..5104862 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KHV99_RS25345 (KHV99_25270) | 5098487..5100007 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| KHV99_RS25350 (KHV99_25275) | 5100004..5101002 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| KHV99_RS25355 (KHV99_25280) | 5101033..5101974 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| KHV99_RS25360 (KHV99_25285) | 5102049..5103056 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| KHV99_RS25365 (KHV99_25290) | 5103181..5104098 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KHV99_RS25370 (KHV99_25295) | 5104104..5104862 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KHV99_RS25375 (KHV99_25300) | 5104948..5105676 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| KHV99_RS25380 (KHV99_25305) | 5105949..5108096 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| KHV99_RS25385 (KHV99_25310) | 5108326..5109012 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T202334 WP_002885155.1 NZ_CP074541:c5104098-5103181 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T202334 NZ_CP099376:659158-659445 [Citrobacter braakii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCTAT
ATTGGTTTTCGACGATCCCCAACACCTGTCGCGGCAGGATCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATCGGTC
TTGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGC
GCCAGAAAGGCAGATCGTAAAGAGAGGAGTCGTTATGAGCATAGTTAA
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCTAT
ATTGGTTTTCGACGATCCCCAACACCTGTCGCGGCAGGATCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATCGGTC
TTGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGC
GCCAGAAAGGCAGATCGTAAAGAGAGGAGTCGTTATGAGCATAGTTAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT202334 WP_004151732.1 NZ_CP074541:c5104862-5104104 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT202334 NZ_CP099376:659432-659734 [Citrobacter braakii]
ATGAGCATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATTGATTACAGCGACATTCCCGTGACCGAGGATGAGCTGTGGTCAGAAGCTCATCGCGGTAAGT
TTTTCCGTCCGTTGAAAACGCAGGCGTCGGTACGTATTGATGCCGATGTGATGGAGTGGCTGAAACGCCCAGGAAAAGGA
TATCAGACGCGCCTAAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAACAAGAAATAG
ATGAGCATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATTGATTACAGCGACATTCCCGTGACCGAGGATGAGCTGTGGTCAGAAGCTCATCGCGGTAAGT
TTTTCCGTCCGTTGAAAACGCAGGCGTCGGTACGTATTGATGCCGATGTGATGGAGTGGCTGAAACGCCCAGGAAAAGGA
TATCAGACGCGCCTAAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAACAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |