Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4944349..4944865 Replicon chromosome
Accession NZ_CP074541
Organism Klebsiella pneumoniae strain S24_CRE24

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KHV99_RS24550 Protein ID WP_002886902.1
Coordinates 4944349..4944633 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KHV99_RS24555 Protein ID WP_002886901.1
Coordinates 4944623..4944865 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV99_RS24525 (KHV99_24450) 4939833..4940096 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KHV99_RS24530 (KHV99_24455) 4940226..4940399 + 174 WP_002886906.1 hypothetical protein -
KHV99_RS24535 (KHV99_24460) 4940402..4941145 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KHV99_RS24540 (KHV99_24465) 4941502..4943640 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KHV99_RS24545 (KHV99_24470) 4943881..4944345 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KHV99_RS24550 (KHV99_24475) 4944349..4944633 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV99_RS24555 (KHV99_24480) 4944623..4944865 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KHV99_RS24560 (KHV99_24485) 4944943..4946853 - 1911 WP_270104185.1 PRD domain-containing protein -
KHV99_RS24565 (KHV99_24490) 4946876..4948030 - 1155 WP_002886900.1 lactonase family protein -
KHV99_RS24570 (KHV99_24495) 4948096..4948836 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T202333 WP_002886902.1 NZ_CP074541:c4944633-4944349 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T202333 NZ_CP099375:4888145-4888453 [Citrobacter braakii]
ATGCATGTTATCAGCCGAAAACCTTTCAACGAGGCAATACTCCGTTTTCCAAACCACATGGCAGCACTCGTTGATTTGCT
GAATATTTTAGAGAAAAAAATGTTCCACACTCCTGAAGAGATGAAGCAGTACATACCTTCACTGGATAATTTTAAATACA
GAAATAAATGGTGGGTGATTAATGTTTCAGGTAACTGCTTGAGACTTATTGCCTATATTGATTTCAAACTGCAAAAGGTA
TTTGTGAAGCATATCGTTCACCATGCCGAGTATGACAGACTAACCACATACTATCGGGGTCACAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT202333 WP_002886901.1 NZ_CP074541:c4944865-4944623 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT202333 NZ_CP099375:4888453-4888905 [Citrobacter braakii]
ATGAGAACGCATGAAAGCCATCAGATAGACACAGCCAGTGTAAAATTGATGATCGATACCTTTACCGATGCAGTGAAAAA
AATCCCCCTGTTAGGCAAAGAACAAAATGAGGCAGAGTACCGAAAAGCACTCGCTTTGGTGGAGTATCTGGTTGATCGTG
ACGACCTGGAAAACCCGTTGTTTGAGCTGCTTTCAGCTCGGATCCGCGACTACGAAAAACATGCGCCTGAGTTCAGTGCC
CTCAACCAACAACTGGAACATACTCCTCATGGCGTTACGTTACTGCGTACGCTCATGGATCAATATGGTCTCAAAGCAGC
AGATCTTGCCAACGAACTTGGTTCAAAATCCAATGTCAGCAACATCTTGAATGGTCGCAGAGCACTGACTGTAAGTCATA
TTAAAATGCTCGCAGAGCGCTTTAACCTTCCGGCAGACGCATTCATCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References